Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma

Table 3

Expression of proinflammatory cytokine mRNA by AM.

Cytokine	Naïve	𝛽GL-113	Anti-IL-33
TNF-𝛼	0.01 ± 0.01	1.20 ± 0.35**	0.29 ± 0.14^#
IL-1𝛽	0.03 ± 0.00	1.95 ± 0.74	0.76 ± 0.36
IL-6	0.00 ± 0.00	0.37 ± 0.11**	0.02 ± 0.01^#
CXCL-1	0.05 ± 0.02	0.35 ± 0.05**	0.09 ± 0.05^##

Data are mean ± SEM (𝑛 = 4–6 animals per group) relative to HPRT. Significant differences relative to the naïve group are shown as **(𝑃<0.01) and those relative to the acute exacerbation group are shown as ^#(𝑃<0.05) and ^##(𝑃<0.01).