Table 1: Late-onset Alzheimer’s disease associated genes/variants.

VariantGeneAbbreviationRisk/protective

rs7412Apolipoprotein EAPOERisk
rs429358Apolipoprotein EAPOEProtective
rs744373Bridging integrator 1BIN1Risk
rs11136000ClusterinCLUProtective
rs3764650ATP-binding cassette, subfamily A (ABC1), member 7ABCA7Risk
rs3818361Complement component (3b/4b) receptor 1 (Knops blood group)CR1Risk
rs3851179Phosphatidylinositol binding clathrin assembly proteinPICALMProtective
rs610932Membrane-spanning 4 domains, subfamily A, member 6AMS4A6AProtective
rs3865444CD33 moleculeCD33Protective
rs670139Membrane-spanning 4 domains, subfamily A, member 4EMS4A4ERisk
rs9349407CD2-associated proteinCD2APRisk

Each of the top variants associated with late-onset Alzheimer’s disease from meta-analysis done by the Alzheimer Research Forum is listed here, together with the specific associated variant, and whether the variant increases risk or provides protection.