Harmine and Harmaline Downregulate TCDD-Induced Cyp1a1 in the Livers and Lungs of C57BL/6 Mice

Table 2

Summary of the effects of harmine and harmaline on TCDD-mediated induction of Cyp1a1 in livers and lungs of C57BL/6 mice.

		Harmine	Harmaline
	TCDD-induced
Liver	(i) mRNA Cyp1a1	↓ 15%	↓ 9%
	(ii) Protein Cyp1a	↓ 17%	↓ 20%
	(iii) Activity Cyp1a1	↓ 60%	↓ 32%
	TCDD-induced
Lung	(i) mRNA Cyp1a1	↓ 44%	↓ 34%
	(ii) Protein Cyp1a	↓ 43%	↓ 44%
	(iii) Activity Cyp1a1	↓ 60%	↓ 40%