Mesenchymal Stem Cell-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Ameliorate Diabetic Polyneuropathy in Mice
Figure 7
Neurophysiological evaluations. (a) All of current perception thresholds (CPTs) were impaired in diabetic mice and the impairments were ameliorated in the transplanted limbs. (b) The thermal plantar test clarified the impairments of thermal perception in diabetic mice and the impairments were ameliorated in the transplanted limbs. (c) Motor and sensory nerve conduction velocity (MNCV and SNCV, respectively) decreased in diabetic mice compared with those in nondiabetic mice. The SNCV increased in the transplanted limbs of diabetic mice. compared with pretransplanted nondiabetic mice, compared with posttransplanted mice, compared with non-T. D: diabetic mice, N: nondiabetic mice, con-T: contralateral limbs of transplanted mice, and ipsi-T: ipsilateral limbs of transplanted mice. in each group.
