Table 2: Effect of benzene fraction of Murraya koenigii on the mutagenicity induced by sodium azide (NaN3) using Salmonella typhimurium strains.

Treatment
Dose (µg/plate)Number of His+ revertants colonies/plate
TA97aTA98TA100TA102

Spontaneous140.0 ± 4.031.0 ± 3.6128.7 ± 9.8245.7 ± 23.3
Positive control (NaN3)1.5246.3 ± 16.052.7 ± 2.1352.0 ± 33.0343.3 ± 33.3
Murraya koenigii 12.5164.3 ± 12.346.0 ± 4.0191.7 ± 13.3286.7 ± 26.3
25145.0 ± 15.537.3 ± 7.0172.3 ± 18.9260.0 ± 24.1
50124.7 ± 9.130.7 ± 8.5153.0 ± 19.7245.3 ± 24.4
100118.0 ± 10.524.0 ± 4.6127.0 ± 15.5228.3 ± 19.6
Murraya koenigii + NaN312.5225.3 ± 33.6 (25.6)51.3 ± 6.0 (20.0)316.3 ± 32.0 (22.3)332.3 ± 34.9 (19.4)
25200.7 ± 22.7* (45.1)45.3 ± 4.2 (47.8)258.0 ± 29.6* (52.3)313.0 ± 32.1 (36.4)
50168.0 ± 22.3** (64.4)39.0 ± 8.2* (62.1)212.7 ± 26.6** (70.0)292.7 ± 18.6 (51.7)
100137.3 ± 12.7*** (84.9)31.7 ± 6.5** (73.2)162.0 ± 21.0** (84.4)260.3 ± 14.0* (72.2)

  value 18.0698.28833.6906.917

  value0.9990.9530.9690.996

The data represented in the table is the mean ± SD values of three replicates. Mean values followed by asterisk are significantly different when compared to positive control at *P < 0.05, **P < 0.005, and ***P < 0.001. The values in parentheses are the inhibition rates of mutagenicity (%). Positive control: NaN3, sodium azide. aNegative control; bpreincubation test; : linear regression analysis.