Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii
Table 3
Effect of benzene fraction of Murraya koenigii on the mutagenicity induced by methyl methanesulfonate (MMS) using Salmonella typhimurium strains.
Treatment
Dose (µg/plate)
Number of His+ revertants colonies/plate
TA97a
TA98
TA100
TA102
Spontaneous
140.0 ± 4.0
31.0 ± 3.6
128.7 ± 9.8
245.7 ± 23.3
Positive control (MMS)
1
443.7 ± 19.9
51.0 ± 2.7
952.7 ± 46.0
1195.3 ± 79.0
Murraya koenigii
12.5
164.3 ± 12.3
46.0 ± 4.0
191.7 ± 13.3
286.7 ± 26.3
25
145.0 ± 15.5
37.3 ± 7.0
172.3 ± 18.9
260.0 ± 24.1
50
124.7 ± 9.1
30.7 ± 8.5
153.0 ± 19.7
245.3 ± 24.4
100
118.0 ± 10.5
24.0 ± 4.6
127.0 ± 15.5
228.3 ± 19.6
koenigii+ MMS
12.5
388.3 ± 31.2 (19.8)
50.3 ± 4.0 (13.4)
802.3 ± 57.1* (19.8)
862.3 ± 58.8** (36.6)
25
309.0 ± 30.8* (45.1)
45.0 ± 4.6 (43.9)
565.0 ± 45.1*** (49.7)
675.3 ± 56.9*** (55.6)
50
239.7 ± 20.2** (63.9)
38.3 ± 4.0* (62.3)
440.7 ± 48.6*** (64.0)
518.0 ± 32.1*** (71.3)
100
183.0 ± 17.5*** (80.0)
31.0 ± 5.6** (74.1)
262.3 ± 31.7*** (83.6)
363.7 ± 37.1*** (86.0)
value treatment
81.635
9.877
225.881
178.255
value
0.989
0.958
0.978
0.996
The data represented in the table is the mean ± SD values of three replicates. Mean values followed by asterisk are significantly different when compared to positive control at *P < 0.05; **P < 0.005 and ***P < 0.001. The values in parentheses are the inhibition rates of mutagenicity (%). Positive control: MMS: methyl methanesulfonate. aNegative control; bPre-incubation; : Linear regression analysis.
