Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii
Table 4
Effect of benzene fraction of Murraya koenigii on the mutagenicity induced by benzo(a)pyrene with metabolic activation using Salmonella typhimurium strains.
Treatment
Dose (µg/plate)
Number of His+ revertants colonies/plate
TA97a
TA98
TA100
TA102
Spontaneous
143.7 ± 13.2
37.0 ± 3.0
135.3 ± 9.5
316.0 ± 14.5
Positive control (BP)
1
720.3 ± 28.5
155.0 ± 7.6
695.7 ± 17.0
648.0 ± 17.1
koenigii
12.5
142.0 ± 18.3
50.3 ± 2.5
132.7 ± 16.0
265.0 ± 28.2
25
156.0 ± 14.4
42.7 ± 3.5
155.3 ± 17.2
296.3 ± 17.6
50
168.7 ± 21.7
35.0 ± 3.6
322.7 ± 31.1
100
181.3 ± 27.1
28.0 ± 3.6
175.3 ± 20.6
340.3 ± 31.3
koenigii+ BP
12.5
592.3 ± 44.5* (22.1)
132.7 ± 19.2 (21.3)
540.0 ± 50.1** (27.7)
560.3 ± 31.2* (22.9)
25
501.7 ± 36.6** (38.7)
101.0 ± 19.3* (48.1)
435.3 ± 46.1*** (48.2)
501.7 ± 16.9*** (41.9)
50
382.7 ± 35.6*** (61.2)
(61.9)
352.3 ± 30.7*** (65.1)
436.0 ± 38.2*** (65.2)
100
276.0 ± 26.5*** (82.4)
(80.1)
253.7 ± 21.4*** (84.9)
382.0 ± 29.2*** (86.0)
value treatment
168.149
49.036
149.651
67.488
value
0.996
0.982
0.999
0.999
The data represented in the table is the mean ± SD values of three replicates. Mean values followed by asterisk are significantly different when compared to positive control at *P < 0.05; **P < 0.005 and ***P < 0.001. The values in parentheses are the inhibition rates of mutagenicity (%). Positive control: BP: benzo(a)pyrene.aNegative control; bPre-incubation test; : Linear regression analysis.
