Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii
Table 5
Effect of benzene fraction of Murraya koenigii on the mutagenicity induced by 2-aminofluorene (2-AF) with metabolic activation using Salmonella typhimurium strains.
Treatment
Dose (µg/plate)
Number of His+ revertants colonies/plate
TA97a
TA98
TA100
TA102
Spontaneous
143.7 ± 13.2
37.0 ± 3.0
135.3 ± 9.5
316.0 ± 14.5
Positive control (2AF)
5
328.0 ± 12.0
262.3 ± 17.2
502.0 ± 19.1
1430.3 ± 32.5
Murraya koenigii
12.5
142.0 ± 18.3
50.3 ± 2.5
132.7 ± 16.0
265.0 ± 28.2
25
156.0 ± 14.4
42.7 ± 3.5
155.3 ± 17.2
296.3 ± 17.6
50
168.7 ± 21.7
35.0 ± 3.6
322.7 ± 31.1
100
181.3 ± 27.1
28.0 ± 3.6
175.3 ± 20.6
340.3 ± 31.3
Murraya koenigii+ 2-AF
12.5
276.3 ± 31.1 (27.8)
200.7 ± 17.0* (29.1)
422.3 ± 32.7* (21.6)
1185.3 ± 77.0** (21.0)
25
248.7 ± 28.0* (46.1)
161.0 ± 12.5** (46.1)
346.3 ± 21.6*** (44.9)
960.7 ± 70.8*** (41.4)
50
220.0 ± 25.0** (67.8)
114.7 ± 13.1*** (65.0)
280.7 ± 27.0*** (66.3)
655.0 ± 55.3*** (70.0)
100
202.3 ± 14.2*** (85.7)
70.0 ± 7.6*** (82.1)
205.0 ± 18.0*** (90.9)
462.0 ± 32.9*** (88.8)
value treatment
24.643
197.239
37.820
276.179
value
0.987
0.999
0.999
0.994
The data represented in the table is the mean ± SD values of three replicates. Mean values followed by asterisk are significantly different when compared to positive control at *P < 0.05; **P < 0.005 and ***P < 0.001. The values in parentheses are the inhibition rates of mutagenicity (%). Positive control: 2-AF, 2-aminoflourene.aNegative control; bPre-incubation test; : Linear regression analysis.
