A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee

Table 6

GO analysis of molecular function at levels 2 and 3. 𝑃 values are computed by chi-square test with Bonferroni correction.

GO term	GO category	P value	Obs./exp.
Level 2
GO:0003824	Catalytic activity	1.53×10^−33	1.78
GO:0005488	Binding	1.41×10^−27	0.62
GO:0005215	Transporter activity	4.72×10^−14	2.08
GO:0030528	Transcription regulator activity	3.31×10^−5	0.37
GO:0015457	Auxiliary transport protein activity	4.18×10^−3	3.92
GO:0005198	Structural molecule activity	1.01×10^−2	0.40
Level 3
GO:0022857	Transmembrane transporter activity	7.32×10^−31	3.10
GO:0004133	Glycogen debranching enzyme activity	4.35×10^−30	71.2
GO:0016740	Transferase activity	4.10×10^−28	2.52
GO:0022892	Substrate-specific transporter activity	1.64×10^−25	2.83
GO:0043167	Ion binding	3.89×10^−24	0.12
GO:0003676	Nucleic acid binding	1.42×10^−14	0.23
GO:0000166	Nucleotide binding	6.41×10^−11	0.15
GO:0016491	Oxidoreductase activity	8.19×10^−9	2.31
GO:0005515	Protein binding	2.84×10^−6	0.67
GO:0016787	Hydrolase activity	3.77×10^−6	1.61
GO:0016787	Transcription factor activity	1.97×10^−5	0.07
GO:0016787	Channel regulator activity	9.61×10^−4	4.97
GO:0016787	Bacterial binding	9.69×10^−4	8.21
GO:0016787	Cell surface binding	3.80×10^−3	5.93
GO:0016787	Peptide binding	4.77×10^−2	1.90
GO:0016787	Signal transducer activity	9.11×10^−2	1.35