Review Article

The Predictive Value of Interim and Final [18F] Fluorodeoxyglucose Positron Emission Tomography after Rituximab-Chemotherapy in the Treatment of Non-Hodgkin's Lymphoma: A Meta-Analysis

Table 1

Characteristics of the 13 studies included in the meta-analysis.

StudyPublication yearNo. of NHL patientsStudy designStageFunctional imagingPET timingSurvival dataPET (+) as prognostic factor for survivalMethodology score (%)

Zinzani et al. [7]2011DLBCL ( )  PMLBCL ( )RetrospectiveStage II–IV PETI-PETOS & PFSSignificant65.79%
Yoo et al. [8]2011DLBCL ( )RetrospectiveStage I–IVPET/CTI-PET, final PETOS & PFSUndetermined78.95%
Yang et al. [9]2011DLBCL ( )ProspectiveStage I–IVPET/CTI-PETOS & PFSSignificant89.47%
Trotman et al. [10]2011FL ( )ProspectiveStage III-IVPET/CTF-PETOS & PFSSignificant71.05%
Safar et al. [11]2012DLBCL ( )RetrospectiveStage III-IVPETI-PETOS & PFSSignificant71.05%
Pregno et al. [12]2012DLBCL ( )RetrospectiveStage I–IVPET/CTI-PET, F-PETPFSUndetermined78.95%
Le Dortz et al. [13]2010FL ( )RetrospectiveStage I–IVPET/CTF-PETPFSSignificant71.05%
Han et al. [14]2009DLBCL ( ) 
MCL ( )
RetrospectiveStage I–IVPETI-PET, F-PETOS & PFSUndetermined63.16%
Cox et al. [15]2012DLBCL ( ) PMLBCL ( )ProspectiveStage I–IVPETI-PETOS & PFSUndetermined76.68%
Cashen et al. [16]2011DLBCL ( )ProspectiveStage III-IVPET/CTI-PET, F-PETOS & PFSSignificant71.05%
Mato et al. [17]2012MCL ( )RetrospectiveN/APET/CTI-PET, F-PETOS & PFSF-PET: significant I-PET: undetermined50.00%
Lanic et al. [18]2012DLBCL ( )RetrospectiveN/APETI-PETOS & PFSSignificant71.05%
Dupuis et al. [19]2012FL ( )Prospective Grade 1 to 3APETI-PET, F-PETOS & PFSSignificant (OS of I-PET: undetermined)84.21%