Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats
Figure 4
Comparison of the effects of H2-receptor antagonists on cisplatin-induced ileal mucosal damage as evaluated by immunostaining with PGM34. The animals were given cisplatin 6 mg/kg i.v. and were sacrificed 3 days after treatment. The villus height of the ileum significantly decreased in the cisplatin group as compared with the control group and significantly increased in the cisplatin + Laf group as compared with the cisplatin group. Means (±SE) (each group); Fam: famotidine; Laf: lafutidine; .
