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BioMed Research International
Volume 2013 (2013), Article ID 276498, 9 pages
http://dx.doi.org/10.1155/2013/276498
Research Article

NSOM/QD-Based Visualization of GM1 Serving as Platforms for TCR/CD3 Mediated T-Cell Activation

1Laboratory of Nanophotonic Functional Materials and Devices, South China Normal University, Guangzhou, Guangdong 510006, China
2Department of Microbiology & Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, Chicago, IL 60612, USA

Received 19 May 2013; Revised 5 September 2013; Accepted 19 September 2013

Academic Editor: Enzo Terreno

Copyright © 2013 Liyun Zhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. D. Billadeau, J. C. Nolz, and T. S. Gomez, “Regulation of T-cell activation by the cytoskeleton,” Nature Reviews Immunology, vol. 7, no. 2, pp. 131–143, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Yokosuka, W. Kobayashi, K. Sakata-Sogawa et al., “Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C θ translocation,” Immunity, vol. 29, no. 4, pp. 589–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Yokosuka, K. Sakata-Sogawa, W. Kobayashi et al., “Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76,” Nature Immunology, vol. 6, no. 12, pp. 1253–1262, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Varma, G. Campi, T. Yokosuka, T. Saito, and M. L. Dustin, “T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster,” Immunity, vol. 25, no. 1, pp. 117–127, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. S. Shaw and M. L. Dustin, “Making the T cell receptor go the distance: a topological view of T cell activation,” Immunity, vol. 6, no. 4, pp. 361–369, 1997. View at Scopus
  6. S. Minguet, M. Swamy, B. Alarcón, I. F. Luescher, and W. W. A. Schamel, “Full activation of the T cell receptor requires both clustering and conformational changes at CD3,” Immunity, vol. 26, no. 1, pp. 43–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Shen, V. K. Thomas, M. L. Dustin, and L. C. Kam, “Micropatterning of costimulatory ligands enhances CD4+ T cell function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 22, pp. 7791–7796, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. L. DeMond, K. D. Mossman, T. Starr, M. L. Dustin, and J. T. Groves, “T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation,” Biophysical Journal, vol. 94, no. 8, pp. 3286–3292, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Zhong, G. Zeng, X. Lu et al., “NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation,” PLoS ONE, vol. 4, no. 6, Article ID e5945, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. R. Marwali, M. A. MacLeod, D. N. Muzia, and F. Takei, “Lipid rafts mediate association of LFA-1 and CD3 and formation of the immunological synapse of CTL,” Journal of Immunology, vol. 173, no. 5, pp. 2960–2967, 2004. View at Scopus
  11. J. S. Mitchell, O. Kanca, and B. W. McIntyre, “Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes,” Journal of Immunology, vol. 168, no. 6, pp. 2737–2744, 2002. View at Scopus
  12. B. J. Nichols, A. K. Kenworthy, R. S. Polishchuk et al., “Rapid cycling of lipid raft markers between the cell surface and golgi complex,” Journal of Cell Biology, vol. 152, no. 3, pp. 529–541, 2001. View at Scopus
  13. F. Ciesielski, B. Davis, M. Rittig, B. B. Bonev, and O. 'Shea P, “Receptor-independent interaction of bacterial lipopolysaccharide with lipid and lymphocyte membranes, the role of cholesterol,” PLoS One, vol. 7, no. 6, Article ID e38677, 2012.
  14. A. K. Rouquette-Jazdanian, C. Pelassy, J.-P. Breittmayer, and C. Aussel, “Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling,” Cellular Signalling, vol. 18, no. 1, pp. 105–122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. L. Smeets, W. W. M. Fleuren, X. He et al., “Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling,” BMC Immunology, vol. 13, no. 1, p. 12, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Sun, C. W. Arendt, W. Ellmeier et al., “PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes,” Nature, vol. 404, no. 6776, pp. 402–407, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Pfeifhofer, K. Kofler, T. Gruber et al., “Protein kinase C θ affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells,” Journal of Experimental Medicine, vol. 197, no. 11, pp. 1525–1535, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. O. O. Glebov and B. J. Nichols, “Lipid raft proteins have a random distribution during localized activation of the T-cell receptor,” Nature Cell Biology, vol. 6, no. 3, pp. 238–243, 2004. View at Scopus
  19. E. Betzig and R. J. Chichester, “Single molecules observed by near-field scanning optical microscopy,” Science, vol. 262, no. 5138, pp. 1422–1425, 1993. View at Scopus
  20. L. Zhong, Z. Zhang, X. Lu et al., “NSOM/QD-based fluorescence-topographic image fusion directly reveals nano-spatial peak-valley polarities of CD69 and CD71 activation molecules on cell-membrane fluctuations during T-cell activation,” Immunology Letters, vol. 140, no. 1-2, pp. 44–51, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Chen, L. Shao, Z. Ali, J. Cai, and Z. W. Chen, “NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal Vγ2Vδ2 T-cell expansion,” Blood, vol. 111, no. 8, pp. 4220–4232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Zeng, J. Chen, L. Zhong et al., “NSOM- and AFM-based nanotechnology elucidates nano-structural and atomic-force features of a Y. pestis V immunogen-containing particle vaccine capable of eliciting robust response,” Proteomics, vol. 9, no. 6, pp. 1538–1547, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Viola, “The amplification of TCR signaling by dynamic membrane microdomains,” Trends in Immunology, vol. 22, no. 6, pp. 322–327, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Kiyokawa, T. Baba, N. Otsuka, A. Makino, S. Ohno, and T. Kobayashi, “Spatial and functional heterogeneity of sphingolipid-rich membrane domains,” Journal of Biological Chemistry, vol. 280, no. 25, pp. 24072–24084, 2005. View at Publisher · View at Google Scholar · View at Scopus