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BioMed Research International
Volume 2013 (2013), Article ID 280496, 10 pages
http://dx.doi.org/10.1155/2013/280496
Research Article

Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium

1Unidad de Medicina Experimental, Hospital General de México, México, DF 06726, Mexico
2Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México, DF 04510, Mexico
3Departamento de Medicina Experimental, Hospital General de México, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF 06726, Mexico

Received 7 August 2012; Revised 28 September 2012; Accepted 12 October 2012

Academic Editor: Abhay R. Satoskar

Copyright © 2013 Galileo Escobedo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T. solium adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans. Tamoxifen is an antiestrogenic drug with cysticidal action on Taenia crassiceps, a close relative of T. solium. Thus, we evaluated the effect of tamoxifen on the in vitro evagination and the in vivo establishment of T. solium. In vitro, tamoxifen inhibited evagination of T. solium cysticerci in a dose-time dependent manner. In vivo, administration of tamoxifen to hamsters decreased the intestinal establishment of the parasite by 70%, while recovered tapeworms showed an 80% reduction in length, appearing as scolices without strobilar development. Since tamoxifen did not show any significant effect on the proliferation of antigen-specific immune cells, intestinal inflammation, and expression of Th1/Th2 cytokines in spleen and duodenum, this drug could exert its antiparasite actions by having direct detrimental effects upon the adult tapeworm. These results demonstrate that tamoxifen exhibits a strong cysticidal and antitaeniasic effect on T. solium that should be further explored in humans and livestock.