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BioMed Research International
Volume 2013 (2013), Article ID 280810, 7 pages
http://dx.doi.org/10.1155/2013/280810
Research Article

Triterpene Esters and Biological Activities from Edible Fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae

1Laboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil
2Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil
3Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Outeiro São João Batista s/n, Centro 24020-141 Niterói, RJ, Brazil
4Departamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Dr. Francisco Portela 1470, P 24435-000 São Gonçalo, RJ, Brazil
5Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil
6Laboratório de Pesquisa em Fármacos, Colegiado de Ciências Farmacêuticas, Universidade Federal do Amapá, Campus Universitário-Marco Zero do Equador, Rod. Juscelino Kubitschek de Oliveira, KM-02, Bairro Zerão, 68902-280 Macapá, AP, Brazil

Received 6 July 2012; Accepted 11 September 2012

Academic Editor: Didier Bereau

Copyright © 2013 Caio P. Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guracica.” Studies with Manilkara spp. indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp. such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.