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BioMed Research International
Volume 2013 (2013), Article ID 283635, 15 pages
http://dx.doi.org/10.1155/2013/283635
Review Article

Molecular Markers for Prostate Cancer in Formalin-Fixed Paraffin-Embedded Tissues

Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain

Received 29 August 2013; Accepted 10 October 2013

Academic Editor: Renato Franco

Copyright © 2013 Tamara Sequeiros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. Although this approach leads to a confident diagnosis in most cases, it can be improved by using the molecular markers present in the tissue. Both miRNAs and proteins are considered excellent candidates for biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues, due to their stability over long periods of time. In the last few years, a concerted effort has been made to develop the necessary tools for their reliable measurement in these types of samples. Furthermore, the use of these kinds of markers may also help in establishing tumor grade and aggressiveness, as well as predicting the possible outcomes in each particular case for the different treatments available. This would aid clinicians in the decision-making process. In this review, we attempt to summarize and discuss the potential use of microRNA and protein profiles in FFPE tissue samples as markers to better predict PCa diagnosis, progression, and response to therapy.