Molecular Markers for Prostate Cancer in Formalin-Fixed Paraffin-Embedded Tissues

Table 1

miRNAs as PCa biomarkers in FFPE tissue.

miRNA	Clinical significance	References
Let-7 family	Diagnosis, prognosis (↓)	[45, 52]
miR-17	Diagnosis, prognosis (↓)	[154, 155]
miR-19a	Diagnosis	[156]
miR-20a/b	Diagnosis	[154]
miR-21	Prognosis (↑), treatment outcome	[157]
miR-25	Diagnosis	[156]
miR-26a	Diagnosis (↓)	[21]
miR-29a	Diagnosis (↓)	[21, 158]
miR-29b	Diagnosis (↓)	[159]
miR-31-5p	Diagnosis (↓)	[66]
miR-30d	Diagnosis (↑)	[21]
miR-34a	Diagnosis (↓)	[21, 160]
miR-34c-5p	Diagnosis (↓)	[66]
miR-93	Diagnosis	[154]
miR-101	Diagnosis	[154]
miR-106a	Diagnosis	[154]
miR-125b	Diagnosis (↑)	[25]
miR-126	Diagnosis (↓)	[21]
miR-132	Prognosis (↓), treatment outcome	[161]
miR-141	Diagnosis	[154]
miR-143	Diagnosis, prognosis (↓)	[43, 51, 156]
miR-145	Diagnosis, prognosis (↓)	[43, 49–51, 154, 162]
miR-146a/b-5p	Diagnosis, prognosis (↓)	[163]
miR-183-96-182 cluster	Diagnosis, prognosis	[56, 59, 66, 154, 164]
miR-187	Diagnosis	[156]
miR-195	Diagnosis (↓)	[21]
miR-200a	Treatment outcome	[56]
miR-203	Diagnosis, prognosis (↓)	[164]
miR-214	Diagnosis	[154]
miR-221	Diagnosis, prognosis (↓), treatment outcome	[55, 154]
miR-222	Diagnosis	[154]
miR-342-3p	Diagnosis (↑)	[21]
miR-375	Diagnosis (↑)	[43, 154]
miR-519d	Prognosis (↑), treatment outcome	[67]
miR-616	Diagnosis (↑)	[165]
miR-622	Diagnosis (↑)	[21]
miR-647	Prognosis (↓), treatment outcome	[67]
miR-720	Diagnosis	[154]
miR-768-3p	Diagnosis	[154]
miR-1256	Diagnosis (↓)	[158]

Arrows indicate the sense of deregulation: (↑): upregulation; (↓): downregulation in PCa versus normal tissues or low risk versus high risk PCa.