Immunoinformatic Docking Approach for the Analysis of KIR3DL1/HLA-B Interaction
Figure 1
Contribution of epitope Bw4/Bw6 in KIR3DL1 interaction. Here is shown the strength of interaction between HLA-B alleles carrying epitope Bw4 and Bw6 as the difference in the estimated binding free energy () between the substituted peptide and the reference. The higher is the value the stronger is the interaction. (a) Overall interaction between HLA-B alleles grouped based on carrying epitope Bw4 or Bw6. (b) Interaction of each HLA-B allele with KIR3DL1*001: the comparison between HLA-B alleles belonging to the same supertype has been performed. Each HLA-B distribution is composed by 180 points corresponding to each complex with a single-peptide amino acid substitution and is reported as 10–90 percentile whiskers. All the statistical analysis has been performed using paired, nonparametric, Wilcoxon test.
