Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs with Tachycardia-Induced Systolic Heart Failure
Figure 1
The relative mRNA expression of matrix metalloproteinase type 9 (MMP9), matrix metalloproteinase type 2 (MMP2), neutrophil gelatinase-associated lipocalin (NGAL), and tissue inhibitor of metalloproteinases type 1 (TIMP1) in homogenates from left ventricle (LV) myocardium (a) and biceps femoris (BF) (b) of sham-operated pigs and animals with mild, moderate, and severe HF. Results are expressed in arbitrary units, with a mean value for all control animals considered as 1, separately for each molecule in each tissue. Values are presented as means ± standard error means. stands for the Spearman’ rank correlatory coefficient. The relative mRNA expression of MMP9, MMP2, NGAL, and TIMP1 was, respectively, approximately 30, 4, 30, and 10 times lower in porcine homogenates of BF as compared to porcine homogenates of LV myocardium.
