Analysis of Activated Platelet-Derived Growth Factor β Receptor and Ras-MAP Kinase Pathway in Equine Sarcoid Fibroblasts

Figure 8

Effects of imatinib mesylate on PDGF-BB-stimulated sarcoids-derived cells (EqS) viability. MTS-based assay revealed that PDGF-BB stimulates cell growth as well as FBS and that imatinib decreases cell viability in all the analyzed cell lines in a dose-dependent manner, but with lower efficiency in EqS02a (not expressing E5). The data represent the mean of repeated independent experiments.