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BioMed Research International
Volume 2013 (2013), Article ID 284615, 8 pages
Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies
R&D Department, Laboratorios LETI S.L., Calle del Sol 5, Tres Cantos, 28760 Madrid, Spain
Received 30 April 2013; Revised 1 August 2013; Accepted 12 August 2013
Academic Editor: Ralph Mösges
Copyright © 2013 M. Angeles López-Matas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. A. Levy, L. M. Lichtenstein, E. O. Goldstein, and K. Ishizaka, “Immunologic and cellular changes accompanying the therapy of pollen allergy,” Journal of Clinical Investigation, vol. 50, no. 2, pp. 360–369, 1971.
- L. K. James, M. H. Shamji, S. M. Walker et al., “Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies,” Journal of Allergy and Clinical Immunology, vol. 127, no. 2, pp. 509–516, 2011.
- H. Fujita, N. Meyer, M. Akdis, and C. A. Akdis, “Mechanisms of immune tolerance to allergens,” Chemical Immunology and Allergy, vol. 96, pp. 30–38, 2012.
- G. N. Sivalingam and A. J. Shepherd, “An analysis of B-cell epitope discontinuity,” Molecular Immunology, vol. 51, pp. 304–309, 2012.
- A. Gieras, P. Cejka, K. Blatt et al., “Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1,” Journal of Immunology, vol. 186, no. 9, pp. 5333–5344, 2011.
- J. Hecker, A. Diethers, D. Schulz, A. Sabri, M. Plum, Y. Michel, et al., “An IgE epitope of Ber v 1 and fagales PR10 proteins as defined by a human monoclonal IgE,” Allergy, vol. 67, pp. 1530–1537, 2012.
- J.-C. García-Robaina, I. Sánchez, F. de la Torre, E. Fernández-Caldas, and M. Casanovas, “Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae in a double-blind, placebo-controlled study,” Journal of Allergy and Clinical Immunology, vol. 118, no. 5, pp. 1026–1032, 2006.
- C. Colás, S. Monzón, M. Venturini, and A. Lezaun, “Double-blind, placebo-controlled study with a modified therapeutic vaccine of Salsola kali (Russian thistle) administered through use of a cluster schedule,” Journal of Allergy and Clinical Immunology, vol. 117, no. 4, pp. 810–816, 2006.
- A.-S. Höiby, V. Strand, D. S. Robinson, A. Sager, and S. Rak, “Efficacy, safety, and immunological effects of a 2-year immunotherapy with Depigoid birch pollen extract: a randomized, double-blind, placebo-controlled study,” Clinical and Experimental Allergy, vol. 40, no. 7, pp. 1062–1070, 2010.
- O. Pfaar, D. S. Robinson, A. Sager, and R. Emuzyte, “Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis,” Allergy, vol. 65, no. 12, pp. 1614–1621, 2010.
- M. T. Gallego, V. Iraola, M. Himly et al., “Depigmented and polymerised house dust mite allergoid: allergen content, induction of IgG4 and clinical response,” International Archives of Allergy and Immunology, vol. 153, no. 1, pp. 61–69, 2010.
- N. Novak, D. Thaci, M. Hoffmann et al., “Subcutaneous immunotherapy with a depigmented polymerized birch pollen extract: a new therapeutic option for patients with atopic dermatitis,” International Archives of Allergy and Immunology, vol. 155, no. 3, pp. 252–256, 2011.
- O. Pfaar, Z. Urry, D. S. Robinson et al., “A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy,” Allergy, vol. 67, no. 2, pp. 272–279, 2012.
- J. Carnés, M. Himly, M. Gallego et al., “Detection of allergen composition and in vivo immunogenicity of depigmented allergoids of Betula alba,” Clinical and Experimental Allergy, vol. 39, no. 3, pp. 426–434, 2009.
- V. Iraola, M. T. Gallego, M. A. López-Matas et al., “Immunogenicity of Phleum pratense depigmented allergoid vaccines: experimental study in rabbits,” Journal of Investigational Allergology and Clinical Immunology, vol. 22, no. 1, pp. 35–40, 2012.
- P. Adler Würtzen, L. Lund, G. Lund, J. Holm, A. Millner, and H. Henmar, “Chemical modification of birch allergen extract leads to a reduction in allergenicity as well as immunogenicity,” International Archives of Allergy and Immunology, vol. 144, no. 4, pp. 287–295, 2007.
- “Guideline on allergen products: production and quality issues,” EMEA/CHMP/BWP/304831/2007.
- T. Ball, B. Linhart, K. Sonneck et al., “Reducing allergenicity by altering allergen fold: a mosaic protein of Phl p 1 for allergy vaccination,” Allergy, vol. 64, no. 4, pp. 569–580, 2009.
- C. A. Akdis and K. Blaser, “Mechanisms of allergen-specific immunotherapy,” Allergy, vol. 55, no. 6, pp. 522–530, 2000.
- Y. Pico de Coaña, J. Carnés, M. T. Gallego, C. Alonso, and N. Parody, “Modulation of the humoral response to Dermatophagoides pteronyssinus allergens in BALB/c mice by extract modification and adjuvant use,” International Archives of Allergy and Immunology, vol. 157, no. 4, pp. 331–338, 2012.
- M. Casanovas, M. J. Gómez, J. Carnés, and E. Fernández-Caldas, “Skin tests with native, depigmented and glutaraldehyde polymerized allergen extracts,” Journal of Investigational Allergology and Clinical Immunology, vol. 15, pp. 30–36, 2005.
- M. H. Shamji, C. Ljørring, J. N. Francis et al., “Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy,” Allergy, vol. 67, no. 2, pp. 217–226, 2012.
- O. B. Nilsson, J. Adedoyin, C. Rhyner et al., “In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity,” PLoS ONE, vol. 6, no. 9, Article ID e24558, 2011.