Table 4: Steps in evolution of vasculature assessment.

Study Region measuredParameter recommendedMeasured by

Weidner et al. 1991 [7]Hot spot at tumor borderMVDhuman expert
Barbareschi et al. 1995 [25], Simpson et al. 1996 [43], Schoell et al. 1997 [44], Fridman et al. 2000 [45]Hot spots identified on low magnificationEA, MVDCIAS
Belien et al. 1999 [29]Whole slide + hotspotMVDCIAS
Oh et al. 2001 [42]Random spotsMVDCIAS
Kim et al. 2003 [31]Whole slide + hotspotMVD + EACIAS
Chantrain et al. 2003 [32]Entire sampleEACIAS
Mikalsen et al. 2011 [33]Hot spots identified on low magnificationMVDCIAS
Our methodWhole slide + domain specific large hot spotsEACIAS + human expert