Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
Table 1
In vitro, in vivo, and clinical effects of progesterone and its related compounds in HCC.
Progestin
Bioeffect and physical response
Reference
Progesterone
Activation of Src and downstream MAPK induced Elk-1. Transactivation that was nearly as efficient as Elk-1 activation by EGF increase in the % of cells in G2M+ S phase
MA improves HCC patients’ appetite, bodyweight, and a feeling of well-being with minimal side effects. And a minor reduction of tumour size and a prolonged survival