Craniosynostosis-Associated Fgfr2^C342Y Mutant Bone Marrow Stromal Cells Exhibit Cell Autonomous Abnormalities in Osteoblast Differentiation and Bone Formation

Figure 5

Diminished cortical bone volume and density in the long bones of Fgfr2^C342Y/+ mice. Micro-CT analyses demonstrate significantly diminished cortical bone volume/total volume, bone mineral density, and tissue mineral density in tibias of Fgfr2^C342Y/+ (Cz) mice as compared to wild type (WT) mice. ^∗𝑃<.05 between genotypes.

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