Evaluation of the Toxicity of Pradosia huberi Extract during the Preimplantation in Wistar Rats

Table 1

Reproductive variables of rats treated with the hydroalcoholic extract of P. huberi during the preimplantation.

Variables	Hydroalcoholic extract of Pradosia huberi
	Control	1.22 mg/kg	6.1 mg/kg	30.5 mg/kg
Number of inseminated rats	16	16	15	16
Number of pregnant rats	15	11	12	13
Number of corpora lutea	6.4 ± 0.2	5.5 ± 0.4	5.8 ± 0.3	6.9 ± 0.4
Number of uterine implants	11.0 ± 0.1	6.6 ± 1.3*	8.2 ± 1.4*	8.7 ± 1.4*
Number of resorptions	0.1 ± 0.1	0.3 ± 0.2	1.0 ± 0.5*	1.5 ± 0.6*
Gestation index (%)	93.7	68.7	80.0	81.2
Preimplantation loss (%)	14.1	39.2*	28.7*	33.3*

Values are mean ± S.E.M. *𝑃<0.05 versus control.
Gestation index = (number of pregnant females/number of inseminated females) × 100.
Index of preimplantation loss = (number of corpora lutea – number of implants/number of corpora lutea) × 100.