Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes
Figure 3
Effect of derivatives on fibrinogen clotting. Twenty three μM derivatives (gray columns), 46 μM (white columns), or 94 μM (black columns) were incubated with 40 μg/mL B. jararaca (a) or with 10 μg/mL L. muta (b) for 30 min at room temperature. Then, mixture was added to fibrinogen (2 mg/mL) and clotting time was recorded. Venoms were incubated with saline (C1); 1% v/v DMSO (C2); derivative 1 (column 1); derivative 2 (column 2); derivative 3 (column 3); derivative 4 (column 4); derivative 5 (column 5); and with derivative 6 (column 6). # means that fibrinogen did not clot until 600 seconds of observation. Data are expressed as mean ± SEM of individual experiments ().
