IL-17 in the Rheumatologist’s Line of Sight

Figure 2

Effects of IL-17 in the joint. COX2: cyclooxygenase 2; EC: endothelial cells; FLS: fibroblast-like synoviocytes; GM-CSF: granulocyte-monocyte colony-stimulating factor; IFN-γ: interferon-γ; IL: interleukin; MMP: matrix metalloproteinases; NO: nitric oxide; PGE2: prostaglandin E2; RANK: receptor activator of NFκB; RANKL: RANK ligand; TNF-α: tumor necrosis factor-α.