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BioMed Research International
Volume 2013 (2013), Article ID 295204, 6 pages
http://dx.doi.org/10.1155/2013/295204
Clinical Study

Age-Related Changes in Trabecular Meshwork Imaging

1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, 6431 Fannin Street, MSB 7.024, Houston, TX 77030, USA
2Department of Ophthalmology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 6230, San Antonio, TX 78229, USA
3Robert Cizik Eye Clinic, 6400 Fannin Street, Suite 1800, Houston, TX 77030, USA

Received 2 May 2013; Revised 19 July 2013; Accepted 2 August 2013

Academic Editor: Carsten H. Meyer

Copyright © 2013 Mark E. Gold et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images. Patients and Methods. One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length, and area and length of the TM interface shadow from 3 age groups (18–40, 41–60, and 61–80). Measurements were compared using stepwise regression analysis. Results. The average TM parameters were 0.0487 ( ) mm2 for TM area, 0.5502 ( ) mm for TM length, 0.1623 ( ) mm2 for TM interface shadow area, and 0.7755 ( ) mm for TM interface shadow length. Interobserver reproducibility coefficients ranged from 0.45 (TM length) to 0.82 (TM area). TM area and length were not correlated with age. While the TM interface shadow length did not correlate with age, the TM interface shadow area increased with age. Race, sex, intraocular pressure, and gonioscopy score were not correlated with any TM parameters. Conclusion. Although the TM measurements were not correlated with age, the TM interface shadow area increased with age. Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function.