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BioMed Research International
Volume 2013 (2013), Article ID 302392, 13 pages
Membrane Localization of Membrane Type 1 Matrix Metalloproteinase by CD44 Regulates the Activation of Pro-Matrix Metalloproteinase 9 in Osteoclasts
Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
Received 10 March 2013; Revised 22 June 2013; Accepted 22 June 2013
Academic Editor: Sakae Tanaka
Copyright © 2013 Meenakshi A. Chellaiah and Tao Ma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- X. Yu, P. Collin-Osdoby, and P. Osdoby, “SDF-1 increases recruitment of osteoclast precursors by upregulation of matrix metalloproteinase-9 activity,” Connective Tissue Research, vol. 44, supplement 1, pp. 79–84, 2003.
- L. Blavier and J. M. Delaissé, “Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones,” Journal of Cell Science, vol. 108, part 12, pp. 3649–3659, 1995.
- P. Spessotto, F. M. Rossi, M. Degan et al., “Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9,” Journal of Cell Biology, vol. 158, no. 6, pp. 1133–1144, 2002.
- J. S. Nyman, C. C. Lynch, D. S. Perrien et al., “Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone,” Journal of Bone and Mineral Research, vol. 26, no. 6, pp. 1252–1260, 2011.
- M. T. Engsig, Q.-J. Chen, T. H. Vu et al., “Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones,” Journal of Cell Biology, vol. 151, no. 4, pp. 879–889, 2000.
- T. H. Vu, J. M. Shipley, G. Bergers et al., “MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypetrophic chondrocytes,” Cell, vol. 93, no. 3, pp. 411–422, 1998.
- T. Sato, M. D. C. Ovejero, P. Hou et al., “Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts,” Journal of Cell Science, vol. 110, part 5, pp. 589–596, 1997.
- K. Irie, E. Tsuruga, Y. Sakakura, T. Muto, and T. Yajima, “Immunohistochemical localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in osteoclasts in vivo,” Tissue and Cell, vol. 33, no. 5, pp. 478–482, 2001.
- J. Lesley and R. Hyman, “CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells,” European Journal of Immunology, vol. 22, no. 10, pp. 2719–2723, 1992.
- G. F. Weber, S. Ashkar, and H. Cantor, “Interaction between CD44 and osteopontin as a potential basis for metastasis formation,” Proceedings of the Association of American Physicians, vol. 109, no. 1, pp. 1–9, 1997.
- G. N. Thalmann, R. A. Sikes, R. E. Devoll et al., “Osteopontin: possible role in prostate cancer progression,” Clinical Cancer Research, vol. 5, no. 8, pp. 2271–2277, 1999.
- S. Goodison, V. Urquidi, and D. Tarin, “CD44 cell adhesion molecules,” Journal of Clinical Pathology, vol. 52, no. 4, pp. 189–196, 1999.
- M. Seiki, H. Mori, M. Kajita, T. Uekita, and Y. Itoh, “Membrane-type I matrix metalloproteinase and cell migration,” Biochemical Society Symposium, no. 70, pp. 253–262, 2003.
- C. Johnson and Z. S. Galis, “Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 1, pp. 54–60, 2004.
- M. A. Chellaiah and K. A. Hruska, “The integrin αvβ3 and CD44 regulate the actions of osteopontin on osteoclast motility,” Calcified Tissue International, vol. 72, no. 3, pp. 197–205, 2003.
- M. Kajita, Y. Itoh, T. Chiba et al., “Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration,” Journal of Cell Biology, vol. 153, no. 5, pp. 893–904, 2001.
- M. A. Chellaiah, N. Kizer, R. Biswas et al., “Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression,” Molecular Biology of the Cell, vol. 14, no. 1, pp. 173–189, 2003.
- M. A. Chellaiah, R. S. Biswas, S. R. Rittling, D. T. Denhardt, and K. A. Hruska, “Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts,” Journal of Biological Chemistry, vol. 278, no. 31, pp. 29086–29097, 2003.
- J. J. Cao, P. A. Singleton, S. Majumdar et al., “Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44,” Journal of Bone and Mineral Research, vol. 20, no. 1, pp. 30–40, 2005.
- V. Samanna, T. Ma, T. W. Mak, M. Rogers, and M. A. Chellaiah, “Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function,” Journal of Cellular Physiology, vol. 213, no. 3, pp. 710–720, 2007.
- I. Abécassis, B. Olofsson, M. Schmid, G. Zalcman, and A. Karniguian, “RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion,” Experimental Cell Research, vol. 291, no. 2, pp. 363–376, 2003.
- Q. Yu and I. Stamenkovic, “Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion,” Genes and Development, vol. 13, no. 1, pp. 35–48, 1999.
- S. Zucker, M. Drews, C. Conner et al., “Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP),” Journal of Biological Chemistry, vol. 273, no. 2, pp. 1216–1222, 1998.
- J. Zhong, M. M. C. Gencay, L. Bubendorf et al., “ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells,” Journal of Cellular Physiology, vol. 207, no. 2, pp. 540–552, 2006.
- S. Hernandez-Barrantes, Y. Shimura, P. D. Soloway, Q. A. Sang, and R. Fridman, “Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP,” Biochemical and Biophysical Research Communications, vol. 281, no. 1, pp. 126–130, 2001.
- H. F. Bigg, C. J. Morrison, G. S. Butler et al., “Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase a via efficient inhibition of membrane type 1-matrix metalloproteinase,” Cancer Research, vol. 61, no. 9, pp. 3610–3618, 2001.
- G. Dew, G. Murphy, H. Stanton et al., “Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone,” Cell and Tissue Research, vol. 299, no. 3, pp. 385–394, 2000.
- Y. Itoh, A. Takamura, N. Ito et al., “Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion,” EMBO Journal, vol. 20, no. 17, pp. 4782–4793, 2001.
- M. Toth, I. Chvyrkova, M. M. Bernardo, S. Hernandez-Barrantes, and R. Fridman, “Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes,” Biochemical and Biophysical Research Communications, vol. 308, no. 2, pp. 386–395, 2003.
- D. Hoshino, T. Tomari, M. Nagano, N. Koshikawa, and M. Seiki, “A novel protein associated with membrane-type1 matrix metalloproteinase binds p27kip1 and regulates RhoA activation, actin remodeling, and matrigel invasion,” Journal of Biological Chemistry, vol. 284, no. 40, pp. 27315–27326, 2009.
- A. Lal, S. R. Haynes, and M. Gorospe, “Clean western blot signals from immunoprecipitated samples,” Molecular and Cellular Probes, vol. 19, no. 6, pp. 385–388, 2005.
- R. Schmits, J. Filmus, N. Gerwin et al., “CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity,” Blood, vol. 90, no. 6, pp. 2217–2233, 1997.
- M. A. Chellaiah, “Regulation of podosomes by integrin αvβ3 and Rho GTPase-facilitated phosphoinositide signaling,” European Journal of Cell Biology, vol. 85, no. 3-4, pp. 311–317, 2006.
- V. Samanna, H. Wei, D. Ego-Osuala, and M. A. Chellaiah, “Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells,” Experimental Cell Research, vol. 312, no. 12, pp. 2214–2230, 2006.
- B. Desai, M. J. Rogers, and M. A. Chellaiah, “Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells,” Molecular Cancer, vol. 6, article 18, 2007.
- Q. T. Le and N. Katunuma, “Detection of protease inhibitors by a reverse zymography method, performed in a tris(hydroxymethyl)aminomethane-Tricine buffer system,” Analytical Biochemistry, vol. 324, no. 2, pp. 237–240, 2004.
- M. Chellaiah, N. Kizer, M. Silva, U. Alvarez, D. Kwiatkowski, and K. A. Hruska, “Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength,” Journal of Cell Biology, vol. 148, no. 4, pp. 665–678, 2000.
- B. Desai, T. Ma, and M. A. Chellaiah, “Invadopodia and matrix degradation, a new property of prostate cancer cells during migration and invasion,” Journal of Biological Chemistry, vol. 283, no. 20, pp. 13856–13866, 2008.
- E. I. Deryugina, M. A. Bourdon, G. X. Luo, R. A. Reisfeld, and A. Strongin, “Matrix metalloproteinase-2 activation modulates glioma cell migration,” Journal of Cell Science, vol. 110, part 19, pp. 2473–2482, 1997.
- M. A. Chellaiah, N. Soga, S. Swanson et al., “Rho-A is critical for osteoclast podosome organization, motility, and bone resorption,” Journal of Biological Chemistry, vol. 275, no. 16, pp. 11993–12002, 2000.
- A. Y. Strongin, I. Collier, G. Bannikov, B. L. Marmer, G. A. Grant, and G. I. Goldberg, “Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease,” Journal of Biological Chemistry, vol. 270, no. 10, pp. 5331–5338, 1995.
- B. Desai, T. Ma, J. Zhu, and M. A. Chellaiah, “Characterization of the expression of variant and standard CD44 in prostate cancer cells: identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface,” Journal of Cellular Biochemistry, vol. 108, no. 1, pp. 272–284, 2009.
- Q. Yu and I. Stamenkovic, “Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis,” Genes and Development, vol. 14, no. 2, pp. 163–176, 2000.
- S. Hernandez-Barrantes, M. Toth, M. M. Bernardo et al., “Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation,” Journal of Biological Chemistry, vol. 275, no. 16, pp. 12080–12089, 2000.
- P. Hou, T. Troen, M. C. Ovejero et al., “Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption,” Bone, vol. 34, no. 1, pp. 37–47, 2004.
- N. Suenaga, H. Mori, Y. Itoh, and M. Seiki, “CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase,” Oncogene, vol. 24, no. 5, pp. 859–868, 2005.
- M. Goebeler, D. Kaufmann, E.-B. Bröcker, and C. E. Klein, “Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors,” Journal of Cell Science, vol. 109, part 7, pp. 1957–1964, 1996.
- D. Naor, R. V. Sionov, and D. Ish-Shalom, “CD44: structure, function, and association with the malignant process,” Advances in Cancer Research, vol. 71, pp. 241–319, 1997.
- I. Okamoto, Y. Kawano, H. Tsuiki et al., “CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration,” Oncogene, vol. 18, no. 7, pp. 1435–1446, 1999.
- I. Okamoto, Y. Kawano, D. Murakami et al., “Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway,” Journal of Cell Biology, vol. 155, no. 5, pp. 755–762, 2001.
- L. Y. Bourguignon, Z. Gunja-Smith, N. Iida et al., “CD44v(3, 8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells,” Journal of Cellular Physiology, vol. 176, pp. 206–215, 1998.
- H. Nakamura, N. Suenaga, K. Taniwaki et al., “Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase,” Cancer Research, vol. 64, no. 3, pp. 876–882, 2004.
- K. B. Hotary, I. Yana, F. Sabeh et al., “Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes,” Journal of Experimental Medicine, vol. 195, no. 3, pp. 295–308, 2002.
- R. Fridman, M. Toth, I. Chvyrkova, S. O. Meroueh, and S. Mobashery, “Cell surface association of matrix metalloproteinase-9 (gelatinase B),” Cancer and Metastasis Reviews, vol. 22, no. 2-3, pp. 153–166, 2003.
- K. C. Nannuru, M. Futakuchi, M. L. Varney, T. M. Vincent, E. G. Marcusson, and R. K. Singh, “Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-β signaling at the tumor-bone interface,” Cancer Research, vol. 70, no. 9, pp. 3494–3504, 2010.