Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba

Table 7

Biochemical values for female rats receiving PPE for 6 months.

Parameters	Dose of PPE administered (mg/kg/day)
	Water	0.5% tragacanth	11	110	550	1100
	𝑛=15	𝑛=15	𝑛=15	𝑛=14^a	𝑛=15	𝑛=15
ALP (U/L)	22.93±8.00	25.07±7.29	23.80±5.72	21.62±7.68	22.38±6.75	47.33±12.97^∗,#
ALT (U/L)	27.33±4.45	28.60±9.05	26.20±4.99	23.54±4.96	25.07±9.76	29.00±3.68
AST (U/L)	82.67±9.77	87.40±17.22	86.73±11.74	75.15±13.72	63.93±6.57^∗,#	73.60±10.54
Total protein (g/dL)	6.63±0.26	6.49±0.28	6.51±0.35	6.72±0.33	6.99±0.29^∗,#	7.14±0.27^∗,#
Albumin (g/dL)	4.91±0.20	4.82±0.19	4.92±0.26	5.15±0.29^#	5.49±0.70^∗,#	5.81±0.14^∗,#
Total bilirubin (mg/dL)	0.090±0.02	0.098±0.02	0.093±0.02	0.089±0.02	0.077±0.01^#	0.087±0.02
BUN (mg/dL)	20.62±5.44	21.91±5.98	22.73±4.99	25.23±5.97	27.46±5.99^∗	33.39±7.34^∗,#
Creatinine (mg/dL)	0.49±0.08	0.50±0.10	0.51±0.09	0.53±0.13	0.55±0.09	0.68±0.13^∗,#
Glucose (mg/dL)	120.53±16.41	110.66±20.68	113.85±12.41	138.09±24.65^#	156.02±33.38^∗,#	136.70±21.60^#
Uric acid (mg/dL)	3.15±0.84	3.22±0.55	2.83±0.55	3.18±0.65	4.16±1.48	3.83±1.16
Triglyceride (mg/dL)	42.47±9.81	40.74±9.16	40.71±6.06	40.20±10.36	41.81±7.07	33.94±6.50
Cholesterol (mg/dL)	65.30±25.78	59.60±15.74	54.69±10.64	74.42±20.54	89.14±17.89^∗,#	115.28±26.26^∗,#
Sodium	142.40±1.18	141.53±1.55	142.20±1.01	142.31±1.11	141.93±0.88	142.20±1.26
Potassium	7.38±0.83	7.66±1.06	7.13±0.56	6.74±0.88	6.81±0.65	6.53±0.68^#
Chloride	106.60±1.45	105.80±1.47	106.07±0.96	105.15±1.41	103.27±2.71^∗,#	103.93±1.16^∗,#

The values are expressed as the mean ± SD.
∗Significantly different from water (𝑃<0.05).
#Significantly different from 0.5% tragacanth (𝑃<0.05).
aDied from feeding extract into respiratory tract.