Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba
Table 8
Histopathological results of male rats receiving PPE for 6 months.
Organs
Microscopic findings
Dose of PPE administered (mg/kg/day)
Water
0.5% tragacanth
11
110
550
1100
Lung
BALT proliferation
5/15
5/15
2/15
5/14
4/15
5/15
Liver
Centrilobular fatty degeneration
0/15
2/15
2/15
1/14
2/15
0/15
Centrilobular hydropic degeneration
0/15
0/15
2/15
1/14
0/15
0/15
Bile ductule hyperplasia
0/15
0/15
0/15
0/14
1/15
10/15*,#
Small intestine
GALT proliferation in submucosa
1/15
1/15
6/15
2/14
1/15
3/15
Large intestine
GALT proliferation in submucosa
1/15
1/15
0/15
1/14
2/15
3/15
Adrenal gland
Cortical fatty infiltration
0/15
2/15
6/15*
6/14*
4/15*
0/15
The results were expressed as the number of rats with pathological findings per total number of rats treated. Significantly different from water . Significantly different from 0.5% tragacanth . BALT: bronchiole-associated lymphoid tissue; GALT: gut-associated lymphoid tissue.
