Research Article

Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba

Table 9

Histopathological results of female rats receiving PPE for 6 months.

OrgansMicroscopic findingsDose of PPE administered (mg/kg/day)
Water0.5% tragacanth111105501100

LungBALT proliferation4/152/153/155/151/152/15
LiverBile ductule hyperplasia0/150/150/150/151/152/15
Dilated sinusoid and congestion0/150/150/150/152/150/15
KidneyCongestion0/150/151/150/152/15 4/15*,#
Dilated tubules0/150/150/150/151/153/15
Mammary glandGlandular hyperplasia4/154/150/15*,#0/15*,#1/156/15
Adrenal glandMedullary congestion2/153/153/153/151/152/15

The results were expressed as the number of rats with pathological findings per total number of rats treated, 1100: the satellite group.
Significantly different from water .
Significantly different from 0.5% tragacanth .
BALT: bronchiole-associated lymphoid tissue; GALT: gut-associated lymphoid tissue.