In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle
Figure 3
In vitro cumulative release of BSA from AMS in 10 mM PB at pH 5.5. The amount of BSA released was calculated as the % of BSA initially present on AMS. For this experiment, 100 mg AMS loaded with 7.8 mg (or mg/m2 available surface area) BSA was introduced in 5 mL PB. The amount of BSA adsorbed on AMS was calculated using the equilibrium surface coverage ( from Figure 2) and the surface area available for protein adsorption (Table 1). The arrows indicate the samples that were characterized with N2 physisorption after the release experiment.
