Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction

<table>Masson’s trichrome staining for assessing interstitial fibrosis in UUO mice. In sham kidney, no fibrosis labeling was seen. The obstructed kidneys show progressive interstitial fibrosis at days 3, 7, and 14 which was apparently ameliorated by rhEPO treatment. For immunohistochemistry, no S100A4 staining was detected in the sham kidneys. In UUO advanced increased S100A4 staining was seen on cells in interstitial area that displays the outline of lymphocytes and some TEC within the fibrosing obstructed kidneys at days 3, 7, and 14. However, decreased of S100A4 expression was observed in UUO mice with rhEPO treatment<b>. </b>Original magnifications ×400.</table>

BioMed Research International

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Figure 2: Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction 

Figure 2 | Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction 