Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction
Figure 4
Western blot analyses depicting S100A4, TGF-β, BMP-7, Smad2/3, Smad1/5/8, and expression in vivo after rhEPO treatment in UUO model. S100A4, TGF-β, Smad2/3, and expression were significantly higher in UUO mice on days 3, 7, and 14 () than in sham or sham + rhEPO. Treatment with rhEPO resulted in a decrease in S100A4, TGF-β, Smad2/3, and expression (). In contrast, BMP-7, and Smad1/5/8 expression were significantly lower in UUO mice on days 3, 7, and 14 () than in sham or sham + rhEPO. Treatment with rhEPO resulted in preserved BMP-7 and Smad1/5/8 expression (). in each group. Each bar represents the mean ± SD. * versus sham group; # versus UUO group.
