Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction

Table 2

The percentage of histopathology changes, such as degree of glomerulosclerosis, tubular atrophy, and interstitial fibrosis in UUO mice.

	Sham		UUO
	Day 0		Day 3		Day 7		Day 14
	Placebo	EPO	Placebo	EPO	Placebo	EPO	Placebo	EPO
Glomerular sclerosis (%)	0.2±0.4	0.2±0.5	0.4±0.5	0.3±0.5	0.6±0.5	0.5±0.6	1.6±0.5	1.5±0.5
Tubular atrophy (%)	0.6±0.5	0.4±0.4	9±2^∗	3±1^#	17±4^∗	7±3^#	46±2^∗	18±3^#
Interstitial fibrosis (%)	0.6±0.5	0.4±0.5	8±3^∗	4±2^#	21±4^∗	9±2^#	49±4^∗	25±4^#

Values are means ± SD.
Significant difference ^∗𝑃<0.05 compared to sham group; ^#𝑃<0.05 compared to UUO group by Mann-Whitney 𝑈 test.