Clinical Study

Factors Affecting Bilirubin Levels during First 48 Hours of Life in Healthy Infants

Table 2

Relationship of delivery modes and anesthesia types with first feeding, first meconium passage times, feeding types, and bilirubin levels.

C/S
Vaginal
(n: 104)
C/S
(n: 284)
General anesthesia
thiopental (n: 39)
Epidural levobupivacaine
(n: 23)
Spinal hyperbaric bupivacaine
(n: 222)

First feeding (hour)0.50
(0.5)
0.1–3
1.50
(1)
0.2–3.0
0.002.00
(1)
0.4–3.0
2.00
(1)
0.5–3.0
1.00
(1)
0.2–3.0
0.20

Breastfeeding77.9
(n: 81)
50.3
(n: 142)
41.0
(n: 16)
56.5
(n: 13)
52.7
(n: 117)
Mixed feeding22.1
(n: 23)
49.2
(n: 139)
0.0056.4
(n: 22)
43.5
(n: 10)
46.8
(n: 104)
0.29
Formula0
(n: 0)
0.5
(n: 1)
2.6
(n: 1)
0
(n: 0)
0.5
(n: 1)

Meconium passage (hour)6.00
(7)
0–26
6.00
(9)
0–36
0.5012.00
(8)
0–36
5.00
(6)
1–24
6.00
(7)
0–28

Cord bilirubin (mg/dL) 1.60
(0.7)
0.3–4.5
1.60
(0.6)
0.5–4
0.621.70
(0.9)
1–3.5
1.50
(0.8)
0.9–2.9
1.60
(0.6)
0.5–4.0
0.70

24 hours bilirubin (mg/dL) 4.20
(2.1)
0.9–9
4.20
(2.1)
0.1–10.6
0.863.70
(2.2)
1.5–8
4.30
(2.2)
1.8–7.9
4.20
(2.1)
0.1–10.6
0.52

48 hours bilirubin (mg/dL) (median) 6.50
(2.9)
1.8–14.9
6.60
(2.5)
0.6–13.9
0.456.50
(2.7)
2.6–12
6.60
(2.7)
3.4–12
6.65
(2.4)
0.6–13.9
0.86

Data presented as median (interquartile range: IQR) (min–max).
Data presented as number (%).
The statistical difference is due to general anesthesia (thiopental) (Kruskal-Wallis test).