Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
Figure 4
Representative immunoblots a of total and phosphorylated forms and summary of densitometry data of phospho-GSK-3β (P-GSK-3β, (a)) and phospho-Akt (P-Akt, (b)) level in mitochondrial fraction in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), (wortmannin), POS + W, lithium, and IMI treated hearts. VDAC was used as control. IC hearts showed high levels of cytosolic P-GSK-3β/GSK-3β and P-Akt/Akt ratios and they were significantly decreased by all the interventions. W annulled the effects of PRE and POS. * versus NIC; # versus IC; ξ versus PRE and POS.
