Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

Figure 6

Thiobarbituric acid reactive substances concentration (TBARS, nmol/mg protein, (a)), reduced glutathione content (GSH, μg/mg protein, (b)) and cytosolic total superoxide dismutase activity (TSOD, % inhibition/mg protein, (c)) in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE+W (wortmannin), POS+W, lithium, and IMI treated hearts. After ischemia and reperfusion TBARS increased, GSH levels diminished and TSOD activity increased. The interventions attenuated these changes, partially preserving the GSH content and diminishing the TSOD activity and TBARS. W reversed the changes produced by PRE and POS. *𝑃<0.05 versus NIC; ^#𝑃<0.05 versus IC; ^ξ𝑃<0.05 versus PRE and POS.

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(b)

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