Table 5: Association status of common haplotypes of TLR4 gene with Diabetic Foot Ulcers. Fifteen haplotypes with a frequency of more than 1% was found out of which one haplotype ACATC ( value = ) was found to be associated with DFU while two haplotypes ATATC ( value = 0.012) and ATGTT ( value = 0.008) were found to be protective against DFU in a north Indian population.

Haplotype Frequency Case, control frequencies Chi square value

ACATC0.2800.355, 0.20415.278
ACATT0.1360.140, 0.1300.1150.7351
ACGTC0.0970.109, 0.0850.830.3623
ACACC0.0820.086, 0.0780.1310.7174
ACGCT0.0770.065, 0.0901.2020.273
ATATC0.0690.042, 0.0976.330.0119
GCATC0.0500.053, 0.0480.0670.7951
GCGTT0.0270.020, 0.0341.0130.3143
ATGCC0.0250.017, 0.0331.5660.2108
ACACT0.0240.033, 0.0151.8090.1786
ATACT0.0220.014, 0.0301.6790.1951
ACGTT0.0190.010, 0.0272.1660.1411
ATGTT0.0180.003, 0.0346.880.0087
GCATT0.0150.008, 0.0221.9610.1614
GCACT0.0130.012, 0.0140.060.8067