DHA Inhibits Protein Degradation More Efficiently than EPA by Regulating the PPARγ/NFκB Pathway in C2C12 Myotubes
Figure 6
Effect of n-3 PUFA on protein degradation in C2C12 myotubes knockdown of PPARγ. After the transfection of C2C12 myotubes with either the negative control Stealth RNAi oligonucleotide or the PPARγ Stealth RNAi oligonucleotide for 48 h, C2C12 myotubes were incubated with 400 μM EPA or 400 μM DHA for 24 h. BSA was used as the fatty acid-free control. Data are expressed as mean ± S.D. of 8 different experiments. BSA = bovine serum albumin, DHA = docosahexaenoic acid, and EPA = eicosapentaenoic acid. Means without a common letter differ, .
