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BioMed Research International
Volume 2013 (2013), Article ID 320560, 11 pages
http://dx.doi.org/10.1155/2013/320560
Research Article

Meta-Analysis: The Efficacy and Safety of Paricalcitol for the Treatment of Secondary Hyperparathyroidism and Proteinuria in Chronic Kidney Disease

1The Department of Nephrology, The Third People's Hospital of Chengdu, The Chongqing Medical University, Chengdu 610031, China
2Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China
3Division of Nephrology, Department of Medicine, Columbia University Medical Center, 622 West 168th Street, PH 4-124, New York, NY 10032, USA

Received 4 April 2012; Revised 18 July 2012; Accepted 9 August 2012

Academic Editor: Sihe Wang

Copyright © 2013 Tianzhao Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Mizobuchi, Y. Aoshima, and T. Akizawa, “CKD-MBD (chronic kidney disease-mineral and bone disorder). CKD-MBD: chronic kidney disease-mineral and bone disorder,” Clinical Calcium, vol. 20, no. 7, pp. 995–1003, 2010. View at Scopus
  2. E. Suchowierska and M. Myśliwiec, “Chronic kidney disease related to mineral and bone disorders,” Polski Merkuriusz Lekarski, vol. 28, no. 164, pp. 138–143, 2010. View at Scopus
  3. H. Komaba, “CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Role of FGF23-Klotho axis in CKD-MBD,” Clinical Calcium, vol. 20, no. 7, pp. 1028–1036, 2010. View at Scopus
  4. S. Fishbane, H. Chittineni, M. Packman, P. Dutka, N. Ali, and N. Durie, “Oral paricalcitol in the treatment of patients with CKD and proteinuria: a randomized trial,” American Journal of Kidney Diseases, vol. 54, no. 4, pp. 647–652, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Alborzi, N. A. Patel, C. Peterson et al., “Paricalcitol reduces albuminuria and inflammation in chronic kidney disease a randomized double-blind pilot trial,” Hypertension, vol. 52, no. 2, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Agarwal, M. Acharya, J. Tian et al., “Antiproteinuric effect of oral paricalcitol in chronic kidney disease,” Kidney International, vol. 68, no. 6, pp. 2823–2828, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. K. J. Martin, E. A. González, M. Gellens, L. L. Hamm, H. Abboud, and J. Lindberg, “19-nor-1-α-25-dihydroxyvitamin D2 (paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis,” Journal of the American Society of Nephrology, vol. 9, no. 8, pp. 1427–1432, 1998. View at Scopus
  8. H. Abboud, D. Coyne, O. Smolenski et al., “A comparison of dosing regimens of paricalcitol capsule for the treatment of secondary hyperparathyroidism in CKD stages 3 and 4,” American Journal of Nephrology, vol. 26, no. 1, pp. 105–114, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Coyne, M. Acharya, P. Qiu et al., “Paricalcitol capsule for the treatment of secondary hyperparathyroidism in stages 3 and 4 CKD,” American Journal of Kidney Diseases, vol. 47, no. 2, pp. 263–276, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. L. A. Greenbaum, N. Benador, S. L. Goldstein et al., “Intravenous paricalcitol for treatment of secondary hyperparathyroidism in children on hemodialysis,” American Journal of Kidney Diseases, vol. 49, no. 6, pp. 814–823, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. E. A. Ross, J. Tian, H. Abboud et al., “Oral paricalcitol for the treatment of secondary hyperparathyroidism in patients on hemodialysis or peritoneal dialysis,” American Journal of Nephrology, vol. 28, no. 1, pp. 97–106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. D. De Zeeuw, R. Agarwal, M. Amdahl et al., “Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial,” The Lancet, vol. 376, no. 9752, pp. 1543–1551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. C. C. Szeto, K. M. Chow, B. C. H. Kwan, K. Y. Chung, C. B. Leung, and P. K. T. Li, “Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin a nephropathy: an uncontrolled trial,” American Journal of Kidney Diseases, vol. 51, no. 5, pp. 724–731, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Cheng, W. Zhang, X. Zhang, X. Li, and J. Chen, “Efficacy and safety of paricalcitol therapy for chronic kidney disease: a meta-analysis,” Clinical Journal of the American Society of Nephrology, vol. 7, no. 3, pp. 391–400, 2012. View at Publisher · View at Google Scholar
  15. T. Shoji, K. Shinohara, E. Kimoto et al., “Lower risk for cardiovascular mortality in oral 1α-hydroxy vitamin D3 users in a haemodialysis population,” Nephrology Dialysis Transplantation, vol. 19, no. 1, pp. 179–184, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Teng, M. Wolf, E. Lowrie, N. Ofsthun, J. M. Lazarus, and R. Thadhani, “Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy,” New England Journal of Medicine, vol. 349, no. 5, pp. 446–456, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Tentori, W. C. Hunt, C. A. Stidley et al., “Mortality risk among hemodialysis patients receiving different vitamin D analogs,” Kidney International, vol. 70, no. 10, pp. 1858–1865, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Mathew, R. J. Lund, L. R. Chaudhary, T. Geurs, and K. A. Hruska, “Vitamin D receptor activators can protect against vascular calcification,” Journal of the American Society of Nephrology, vol. 19, no. 8, pp. 1509–1519, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. R. Jadad, R. A. Moore, D. Carroll et al., “Assessing the quality of reports of randomized clinical trials: is blinding necessary?” Controlled Clinical Trials, vol. 17, no. 1, pp. 1–12, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. J. P. Higgins and S. Green, Cochrane Handbook for Systematic Reviews of Interventions, Cochrane Collaboration, 2008.
  21. J. P. T. Higgins, S. G. Thompson, J. J. Deeks, and D. G. Altman, “Measuring inconsistency in meta-analyses,” British Medical Journal, vol. 327, no. 7414, pp. 557–560, 2003. View at Scopus
  22. J. P. T. Higgins and S. G. Thompson, “Quantifying heterogeneity in a meta-analysis,” Statistics in Medicine, vol. 21, no. 11, pp. 1539–1558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. H. J. Lambers Heerspink, R. Agarwal, D. W. Coyne et al., “The selective vitamin d receptor activator for albuminuria lowering (VITAL) study: study design and baseline characteristics,” American Journal of Nephrology, vol. 30, no. 3, pp. 280–286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group, “KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD),” Kidney International, Supplement, vol. 76, no. 113, pp. S1–S130, 2009.
  25. M. Cozzolino, E. Missaglia, A. Ortiz et al., “Vascular calcification in chronic kidney disease,” Recenti Progressi in Medicina, vol. 101, no. 11, pp. 442–452, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Joki and Y. Tanaka, “CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Atheroma and vascular calcification in hemodialysis patients,” Clinical Calcium, vol. 20, no. 7, pp. 1061–1066, 2010. View at Scopus
  27. J. Bover, A. Aguilar, J. P. Baas et al., “Calcimimetics in the chronic kidney disease-mineral and bone disorder,” International Journal of Artificial Organs, vol. 32, no. 2, pp. 108–121, 2009. View at Scopus
  28. W. G. Goodman, “Recent developments in the management of secondary hyperparathyroidism,” Kidney International, vol. 59, no. 3, pp. 1187–1201, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Slatopolsky, C. Weerts, and J. Thielen, “Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol in uremic patients,” Journal of Clinical Investigation, vol. 74, no. 6, pp. 2136–2143, 1984. View at Scopus
  30. A. J. Brown, J. Finch, and E. Slatopolsky, “Differential effects of 19-nor-1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 on intestinal calcium and phosphate transport,” Journal of Laboratory and Clinical Medicine, vol. 139, no. 5, pp. 279–284, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. R. J. Lund, D. L. Andress, M. Amdahl, L. A. Williams, and R. P. Heaney, “Differential effects of paricalcitol and calcitriol on intestinal calcium absorption in hemodialysis patients,” American Journal of Nephrology, vol. 31, no. 2, pp. 165–170, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Silver, J. Russell, and L. M. Sherwood, “Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 82, no. 12, pp. 4270–4273, 1985. View at Scopus
  33. J. Russell, D. Lettieri, and L. M. Sherwood, “Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene,” Endocrinology, vol. 119, no. 6, pp. 2864–2866, 1986. View at Scopus
  34. J. Silver, T. Naveh-Many, and H. Mayer, “Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat,” Journal of Clinical Investigation, vol. 78, no. 5, pp. 1296–1301, 1986. View at Scopus
  35. T. Okazaki, T. Igarashi, and H. M. Kronenberg, “5'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3,” Journal of Biological Chemistry, vol. 263, no. 5, pp. 2203–2208, 1988. View at Scopus
  36. D. Gupta, S. Brietzke, M. R. Hayden, L. R. Kurukulasuriya, and J. R. Sowers, “Phosphate metabolism in cardiorenal metabolic disease,” Cardiorenal Medicine, vol. 1, no. 4, pp. 261–270, 2011. View at Publisher · View at Google Scholar
  37. J. Kendrick and M. Chonchol, “The role of phosphorus in the development and progression of vascular calcification,” American Journal of Kidney Diseases, vol. 58, no. 5, pp. 826–834, 2011. View at Publisher · View at Google Scholar
  38. M. Teng, M. Wolf, E. Lowrie, N. Ofsthun, J. M. Lazarus, and R. Thadhani, “Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy,” New England Journal of Medicine, vol. 349, no. 5, pp. 446–456, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. D. W. Coyne, M. Grieff, S. N. Ahya, K. Giles, K. Norwood, and E. Slatopolsky, “Differential effects of acute administration of 19-nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients,” American Journal of Kidney Diseases, vol. 40, no. 6, pp. 1283–1288, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. National Kidney Foundation, “KDOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease,” American Journal of Kidney Diseases, vol. 42, supplement 3, pp. S1–S201, 2003.
  41. A. K. Bhalla, E. P. Amento, and T. L. Clemens, “Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation,” Journal of Clinical Endocrinology and Metabolism, vol. 57, no. 6, pp. 1308–1310, 1983. View at Scopus
  42. L. Helming, J. Böse, J. Ehrchen et al., “1α,25-dihydroxyvitamin D3 is a potent suppressor of interferon γ-mediated macrophage activation,” Blood, vol. 106, no. 13, pp. 4351–4358, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Penna and L. Adorini, “1α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation,” Journal of Immunology, vol. 164, no. 5, pp. 2405–2411, 2000. View at Scopus
  44. Y. C. Li, J. Kong, M. Wei, Z. F. Chen, S. Q. Liu, and L. P. Cao, “1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system,” Journal of Clinical Investigation, vol. 110, no. 2, pp. 229–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. Z. Zhang, Y. Zhang, G. Ning, D. K. Deb, J. Kong, and C. L. Yan, “Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 41, pp. 15896–15901, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Slatopolsky, A. Brown, and A. Dusso, “Pathogenesis of secondary hyperparathyroidism,” Kidney International, Supplement, vol. 56, pp. S14–S19, 1999. View at Scopus