Table 2: The quality of the nine studies.

Study yearResearch methodRandomizationBlindingAllocation concealmentWithdrawal and lossIntention to treat analysisBaseline demographic characteristicsJadad scoreQuality

Fishbane et al. [4], 2009Prospective, randomized, placebo-controlled, double-blinded trialComputer generatedDouble-
blinded
AdequateDescriptionUsedSimilar5A

Alborzi et al.[5], 2008A randomized, double-blinded pilot trialComputer generatedDouble-
blinded
AdequateDescriptionUsedSimilar5A

Agarwal et al.[6], 2005Three, randomized, placebo-controlled, double-blinded trialsDouble-
blinded
UnclearUnclearSimilar2B

Martin et al.[7], 1998Randomized, placebo-controlled, double-blinded multi-investigator studyDouble-
blinded
UnclearNoSimilar3B

Abboud et al.[8], 2006Three, prospective, randomized, placebo-controlled, double-blinded multicenter studiesDouble-
blinded
UnclearUnclearSimilar2B

Coyne et al.[9], 2006Three, randomized, placebo-controlled trialsComputer generatedDouble-
blinded
AdequateUnclearSimilar4B

Greenbaum et al.[10], 2007Randomized, placebo-controlled, double-blinded trialDouble-
blinded
UnclearDescriptionUnclearSimilar3B

Ross et al.[11], 2007Randomized, placebo-controlled, double-blinded trialComputer generatedDouble-
blinded
AdequateUnclearSimilar3B

De Zeeuw et al. [12], 2010A multicenter randomized placebo-controlled, double-blinded clinical trialComputer generatedDouble-
blinded
AdequateDescriptionUsedSimilar5A