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BioMed Research International
Volume 2013 (2013), Article ID 324093, 7 pages
http://dx.doi.org/10.1155/2013/324093
Research Article

Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females

1Department of Physiology and Cell Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore-54600, Pakistan
2Department of Physiology, Shalamar Medical and Dental College, Shalimar Link Road, Mughalpura, Lahore-54840, Pakistan
3Department of Physiology, King Edward Medical University, Nelagumbad, Anarkali, Lahore-54000, Pakistan
4Department of Physiology, College of Medicine, University of Dammam, Dammam 34100, Saudi Arabia
5Department of Human Genetics & Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore-54600, Pakistan

Received 28 April 2013; Revised 21 July 2013; Accepted 21 July 2013

Academic Editor: M. Ilyas Kamboh

Copyright © 2013 Adeela Shahid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, height, waist circumference, hip circumference, and blood pressure (BP) were measured. BMI and waist-to-hip ratio (WHR) were calculated. Levels of fasting blood glucose (FBG), insulin, leptin, and leptin receptors were measured by enzyme linked immunosorbent assay (ELISA), and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. The results showed association of FTO gene, rs9939609, with obesity in females (>18 years of age). FTO minor allele increased the risk of obesity by 2.8 times (95% CI = 1.3–6.0) in females. This allele showed association with body weight, BMI, waist circumference, hip circumference, WHR, BP, plasma FBG levels, HOMA-IR, plasma insulin levels, and plasma leptin levels. In conclusion, FTO gene, rs9939609, is associated with BMI and risk of obesity in adult Pakistani females. Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes. However, the above-mentioned findings were not seen in children or males.