Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females

Table 4

Association of FTO rs9939609 variant with anthropometric and metabolic traits in >18 years old female subjects using dominant model.

	TT 𝑛=83	TA/AA 𝑛=55	GLM 𝑃 value	BMI adjusted 𝑃 value	𝑡-test 𝑃 value
Body weight (Kg)	77.5±2.4	90.5±2.7	<0.001*	<0.001*	0.04*
Height (m)	1.5±0.01	1.5±0.01	0.1	0.1	0.03*
BMI (Kg/m^2)	31.1±0.9	35.7±0.9	<0.001*	<0.001*	0.01*
Waist circumference (cm)	94.6±2.3	105±2.0	<0.001*	<0.001*	0.01*
Hip (cm)	112±2.0	119±1.9	<0.001*	<0.001*	0.02*
WHR	0.8±0.008	0.8±0.01	<0.001*	<0.001*	0.06
SBP (mmHg)	116±1.5	124±1.6	<0.001*	<0.001*	0.003*
DBP (mmHg)	80.1±1.1	83.1±1.1	<0.001*	0.001*	0.16
FBS (mg/dL)	93.8±2.4	106±4.8	<0.001*	0.001*	0.008*
Insulin (µIU/mL)	13.0±1.3	19.4±2.8	0.2	0.001*	0.20
HOMA-IR	2.9±0.3	5.2±0.7	0.03*	<0.001*	0.02*
Leptin (ng/mL)	27.5±2.3	32.7±3.2	0.3	<0.001*	0.18
Leptin receptor (ng/mL)	18.9±0.9	15.7±0.6	0.03*	<0.001*	0.03*

Data are presented as mean ± SEM and were compared by 𝑡-test and GLM after adjusting the data for BMI. ^∗𝑃<0.05 was considered as significant.