Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis

Table 2

Differentially expressed genes in PC-treated hTERT-OA 13A FLS compared to the untreated cells.

Biological process	Gene name	Gene ID	Differ.; Expre.; (fold)*	Description
Muscle tissue development	IGFBP5	AW157548	8.57	Insulin-like growth factor binding protein 5
	CACNB4	NM_000726	2.73	Calcium channel, voltage-dependent, beta-4-subunit
	TPM1	AI521618	2.43	Tropomyosin 1 (alpha)
	JAG1	U61276	2.02	Jagged 1 (Alagille syndrome)
	MORF4L2	H43976	1.90	Mortality factor 4 like 2
	NRG1	NM_013957	1.88	Neuregulin 1
	SIRT2	BG722779	1.86	Sirtuin (silent mating type information regulation 2 homolog) 2
	NF1	D12625	1.80	Neurofibromin 1
	OBSL1	BF446688	1.78	Obscurin-like 1
	MBNL1	AA732240	1.73	Muscleblind-like (Drosophila)
	TPM1	NM_000366	1.72	Tropomyosin 1 (alpha)
	CAV2	AA150110	1.67	Caveolin 2
	RXRA	BE675800	1.66	Retinoid X receptor, alpha
	NR2F2	AL554245	1.63	Nuclear receptor subfamily 2, group F, member 2
	TCF7L2	AV721430	1.61	Transcription factor 7-like 2 (T-cell specific, HMG-box)
	TBX2	U28049	−4.17	T-box 2
	ADRB2	NM_000024	−2.36	Adrenergic, beta-2-receptor, surface
	SORT1	BE742268	−1.93	Sortilin 1
	GJC1	NM_005497	−1.77	Gap junction protein, gamma 1, 45 kDa
	CENPF	U30872	−1.77	Centromere protein F, 350/400 ka (mitosin)
	BCL2	NM_000657	−1.71	B-cell CLL/lymphoma 2
	TBX3	U69556	−1.71	T-box 3
	SDC1	NM_002997	−1.65	Syndecan 1
	TBX5	AW269421	−1.54	T-box 5
	RARB	NM_015854	−1.51	Retinoic acid receptor, beta
Skeletal development	ANXA2	D28364	2.17	Annexin A2
	VDR	AA772285	2.11	Vitamin D (1,25-dihydroxyvitamin D3) receptor
	GNAS	AI693143	1.95	GNAS complex locus
	ACAN	NM_001135	1.80	Aggrecan
	COL1A1	AI743621	1.66	Collagen, type I, alpha-1
	COL1A2	AA628535	1.88	Collagen, type I, alpha-2
	COL11A1	NM_001854	1.50	Collagen, type XI, alpha-1
	COL12A1	AU146651	1.93	Collagen, type XII, alpha-1
	MSX2	D89377	1.85	Msh homeobox 2
	GHR	NM_000163	1.76	Growth hormone receptor
	MEF2C	AL536517	1.59	Myocyte enhancer factor 2C
	THRA	NM_003250	1.57	Thyroid hormone receptor, alpha
	RUNX2	AW469546	1.55	Runt-related transcription factor 2
	CLEC3B	NM_003278	1.55	Exosome component 7
	MEF2C	N22468	1.55	Myocyte enhancer factor 2C
	IGFBP4	NM_001552	1.54	Insulin-like growth factor binding protein 4
	PRKRA	AA279462	1.53	Protein kinase, interferon-inducible RNA-dependent activator
	TNFRSF11B	NM_002546	1.50	Tumor necrosis factor receptor superfamily, member 11b
	BMPR1B	AA935461	−2.12	Bone morphogenetic protein receptor, type IB
	ANKH	AF274753	−1.93	Ankylosis, progressive homolog (mouse)
	ACVR2A	NM_001616	−1.89	Activin A receptor, type IIA
	CYTL1	NM_018659	−1.83	Cytokine-like 1
	TBX3	U69556	−1.71	T-box 3 (ulnar mammary syndrome)
	SOX9	NM_000346	−1.71	SRY- (sex-determining-region-Y-) box 9
	FOXC2	NM_005251	−1.68	Forkhead box C2 (MFH-1, mesenchyme forkhead 1)
	KIAA1217	BC017424	−1.66	KIAA1217
	MMP9	NM_004994	−1.61	Matrix metallopeptidase 9
	TGFBR2	NM_003242	−1.51	Transforming growth factor, beta-receptor II (70/80 kDa)
Collagen biosynthetic process	COL3A1	AU146808	1.83	Collagen, type III, alpha-1
	COL1A2	AA628535	1.88	Collagen, type I, alpha-2
	COL1A1	AI743621	1.66	Collagen, type I, alpha-1
	TRAM2	AI986461	1.58	Translocation-associated membrane protein 2
	ITGA2	N95414	−1.74	Integrin, alpha-2 (CD49B, alpha-2 subunit of VLA-2 receptor)
Collagen catabolic process	MMP3	NM_002422	3.18	Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
	ADAMTS5	BI254089	3.32	ADAM metallopeptidase with thrombospondin type 1 motif, 5
	ADAMTS14	W60649	2.15	ADAM metallopeptidase with thrombospondin type 1 motif, 14
	MMP16	U79292	1.80	Matrix metallopeptidase 16 (membrane inserted)
	MMP9	NM_004994	−1.61	Matrix metallopeptidase 9

∗Negative number indicates decreased expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells. Positive number indicates elevated expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells.