Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis

Table 3

Differential expression confirmed by real-time RT-PCR.

Gene name	Gene ID	Differential expression microarray	Differential expression RT-PCR*	Differential expression RT-PCR**
BLM	NM_000057	−3.64	−4.23	−3.95
HELLS	NM_018063	−2.49	−2.87	−2.12
CCNE2	AF112857	−3.74	−3.93	−3.70
CDC25C	NM_001790	−2.31	−2.01	−1.94
EGR1	AI459194	−2.25	−2.45	−3.29
FOSL1	BG251266	−1.95	−2.31	−2.11
PLAUR	U08839	−1.92	−2.41	−3.22
PLA2G4A	M68874	−1.51	−1.86	−2.11
PTGS2	AY151286	−6.09	−5.77	−5.10
TACR1	AA461490	−4.39	−3.92	−3.45
CCL2	S69738	−1.82	−2.02	−1.79
GPR68	AI805006	−2.15	−2.54	−2.28
CACNA1A	BC042451	−2.00	−2.10	−2.22
IGFBP5	AW157548	8.57	6.32	5.46
ADAMTS5	BI254089	3.32	2.81	2.11
COL1A2	AA628535	1.88	1.40	1.64

∗Differential expression—the numbers are the ratio of the relative expression level of a specific gene in PC-treated hTERT-OA 13A FLSs compared with the relative expression level of the specific gene in the untreated hTERT-OA 13A FLSs. ∗∗Differential expression—the numbers are the ratio of the relative expression level of a specific gene in PC-treated primary FLSs compared with the relative expression level of the specific gene in the untreated primary OA FLSs.