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BioMed Research International
Volume 2013 (2013), Article ID 340727, 10 pages
Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord
1Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, CMN-Siglo XXI, IMSS, Avenida Cuauhtémoc 330, Col. Doctores, Delegación Cuauhtémoc, 06720 México, DF, Mexico
2Posgrado en Ciencias en Inmunología, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala, Col. Santo Tomas, 11340 México, DF, Mexico
3Facultad de Ciencias de la Salud, Universidad Anáhuac, México Norte, Avenida Universidad Anáhuac 46, Col. Lomas Anáhuac, 52786 Huixquilucan, MEX, Mexico
4Centro de Investigación del Proyecto CAMINA, A.C, Tlalpan 4430, Col. Toriello Guerra, 14050 México, DF, Mexico
5División de Investigación, Facultad de Medicina, UNAM, Avenida Universidad 3000, 04510 México, DF, Mexico
6Facultad de Estudios Superiores Zaragoza, UNAM, Batalla 5 de Mayo/Fuerte de Loreto, Col. Ejercito de Oriente, 09230 México, DF, Mexico
Received 22 April 2013; Revised 4 September 2013; Accepted 8 September 2013
Academic Editor: Hartmut Jaeschke
Copyright © 2013 Gabriela Bermeo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. J. Dumont, D. O. Okonkwo, S. Verma et al., “Acute spinal cord injury—part I: pathophysiologic mechanisms,” Clinical Neuropharmacology, vol. 24, no. 5, pp. 254–264, 2001.
- B. K. Kwon, W. Tetzlaff, J. N. Grauer, J. Beiner, and A. R. Vaccaro, “Pathophysiology and pharmacologic treatment of acute spinal cord injury,” Spine Journal, vol. 4, no. 4, pp. 451–464, 2004.
- J. W. Rowland, G. W. J. Hawryluk, B. Kwon, and M. G. Fehlings, “Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon,” Neurosurgical Focus, vol. 25, no. 5, article E2, 2008.
- W. Young and I. Koreh, “Potassium and calcium changes in injured spinal cords,” Brain Research, vol. 365, no. 1, pp. 42–53, 1986.
- P. Pacher, J. S. Beckman, and L. Liaudet, “Nitric oxide and peroxynitrite in health and disease,” Physiological Reviews, vol. 87, no. 1, pp. 315–424, 2007.
- S. Cuzzocrea, D. P. Riley, A. P. Caputi, and D. Salvemini, “Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury,” Pharmacological Reviews, vol. 53, no. 1, pp. 135–159, 2001.
- F. Bao and D. Liu, “Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits,” Neuroscience, vol. 115, no. 3, pp. 839–849, 2002.
- K. Chatzipanteli, R. Garcia, A. E. Marcillo, K. E. Loor, S. Kraydieh, and W. D. Dietrich, “Temporal and segmental distribution of constitutive and inducible nitric oxide synthases after traumatic spinal cord injury: effect of aminoguanidine treatment,” Journal of Neurotrauma, vol. 19, no. 5, pp. 639–651, 2002.
- S. Nakahara, K. Yone, T. Setoguchi et al., “Changes in nitric oxide and expression of nitric oxide synthase in spinal cord after acute traumatic injury in rats,” Journal of Neurotrauma, vol. 19, no. 11, pp. 1467–1474, 2002.
- A. Lewén, P. Matz, and P. H. Chan, “Free radical pathways in CNS injury,” Journal of Neurotrauma, vol. 17, no. 10, pp. 871–890, 2000.
- E. Hauben, O. Butovsky, U. Nevo et al., “Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion,” Journal of Neuroscience, vol. 20, no. 17, pp. 6421–6430, 2000.
- E. Hauben, A. Gothilf, A. Cohen et al., “Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury,” Journal of Neuroscience, vol. 23, no. 25, pp. 8808–8819, 2003.
- G. Guízar-Sahagún, A. Ibarra, A. Espitia, A. Martínez, I. Madrazo, and R. E. Franco-Bourland, “Glutathione monoethyl ester improves functional recovery, enhances neuron survival, and stabilizes spinal cord blood flow after spinal cord injury in rats,” Neuroscience, vol. 130, no. 3, pp. 639–649, 2005.
- S. Martiñon, E. García, N. Flores et al., “Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats,” European Journal of Neuroscience, vol. 26, no. 2, pp. 403–412, 2007.
- R. Silva-García and G. Rico-Rosillo, “Anti-inflammatory defense mechanisms of Entamoeba histolytica,” Inflammation Research, vol. 60, no. 2, pp. 111–117, 2011.
- R. Kretschmer, M. L. Collado, and M. G. Pacheco, “Inhibition of human monocyte locomotion by products of axenically grown E. histolytica,” Parasite Immunology, vol. 7, no. 5, pp. 527–543, 1985.
- G. Rico, O. Diaz-Guerra, J. A. Gimenez-Scherer, and R. R. Kretschmer, “Effect of the monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica upon the respiratory burst of human leukocytes,” Archives of Medical Research, vol. 23, no. 2, pp. 157–159, 1992.
- G. Rico, E. Leandro, S. Rojas, J. A. Giménez, and R. R. Kretschmer, “The monocyte locomotion inhibitory factor produced by Entamoeba histolytica inhibits induced nitric oxide production in human leukocytes,” Parasitology Research, vol. 90, no. 4, pp. 264–267, 2003.
- G. Rico, O. Diaz-Guerra, and R. R. Kretschmer, “Cyclic nucleotide changes induced in human leukocytes by a product of axenically grown Entamoeba histolytica that inhibits human monocyte locomotion,” Parasitology Research, vol. 81, no. 2, pp. 158–162, 1995.
- R. Silva-García, I. Estrada-García, R. Ramos-Payán et al., “The effect of an anti-inflammatory pentapeptide produced by Entamoeba histolytica on gene expression in the U-937 monocytic cell line,” Inflammation Research, vol. 57, no. 4, pp. 145–150, 2008.
- D. Utrera-Barillas, J. R. Velazquez, A. Enciso et al., “An anti-inflammatory oligopeptide produced by Entamoeba histolytica down-regulates the expression of pro-inflammatory chemokines,” Parasite Immunology, vol. 25, no. 10, pp. 475–482, 2003.
- J. A. Gimenez Scherer, G. Rico, J. Fernandez-Diez, and R. R. Kretschmer, “Inhibition of contact cutaneous delayed hypersensitivity reactions to DNBC in guinea pigs by the monocyte locomotion inhibitory factor (MLIF) produced by axenically grown Entamoeba histolytica,” Archives of Medical Research, vol. 28, pp. 237–238, 1997.
- J. A. Gimenez-Scherer, E. Arenas, L. Diaz, G. Rico, J. Fernandez, and R. Kretschmer, “Effect of the monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica on the expression of cell adhesion molecules (CAMs) in the skin of guinea pigs,” Archives of Medical Research, vol. 31, no. 4, supplement, pp. S92–S93, 2000.
- A. Ibarra, E. García, N. Flores et al., “Immunization with neural-derived antigens inhibits lipid peroxidation after spinal cord injury,” Neuroscience Letters, vol. 476, no. 2, pp. 62–65, 2010.
- D. M. Basso, M. S. Beattie, and J. C. Bresnahan, “A sensitive and reliable locomotor rating scale for open field testing in rats,” Journal of Neurotrauma, vol. 12, no. 1, pp. 1–21, 1995.
- E. García, R. Silva-García, H. Mestre et al., “Immunization with A91 peptide or copolymer-1 reduces the production of nitric oxide and inducible nitric oxide synthase gene expression after spinal cord injury,” Journal of Neuroscience Research, vol. 90, no. 3, pp. 656–663, 2012.
- S. W. Scheff, D. A. Saucier, and M. E. Cain, “A statistical method for analyzing rating scale data: the BBB locomotor score,” Journal of Neurotrauma, vol. 19, no. 10, pp. 1251–1260, 2002.
- E. Park, A. A. Velumian, and M. G. Fehlings, “The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration,” Journal of Neurotrauma, vol. 21, no. 6, pp. 754–774, 2004.
- F. Bao and D. Liu, “Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3,” Neuroscience, vol. 116, no. 1, pp. 59–70, 2003.
- C. A. Oyinbo, “Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade,” Acta Neurobiologiae Experimentalis, vol. 71, no. 2, pp. 281–299, 2011.
- K. K. Eun, W. K. Jung, S. K. Ku et al., “The role of inducible nitric oxide synthase following spinal cord injury in rat,” Journal of Korean Medical Science, vol. 20, no. 4, pp. 663–669, 2005.
- S. Rojas-Dotor, J. Pérez-Ramos, J. A. Giménezscherer, F. Blanco-Favela, and G. Rico-Rosillo, “Effect of the monocyte locomotion inhibitory factor (MLIF) produced by E. histolityca on cytokines and chemokine receptors in T CD4+ lymphocytes,” Biological Research, vol. 42, no. 4, pp. 415–425, 2009.
- O. N. Hausmann, “Post-traumatic inflammation following spinal cord injury,” Spinal Cord, vol. 41, no. 7, pp. 369–378, 2003.
- H. Jiang, J. Li, X. Zhao et al., “Determination of an unstable pentapeptide, monocyte locomotion inhibitory factor, in dog blood by LC-MS/MS: application to a pharmacokinetic study,” Journal of Pharmaceutical and Biomedical Analysis, vol. 83, pp. 305–313, 2013.
- D. Gris, E. F. Hamilton, and L. C. Weaver, “The systemic inflammatory response after spinal cord injury damages lungs and kidneys,” Experimental Neurology, vol. 211, no. 1, pp. 259–270, 2008.
- Y. Zhang, J. Chen, F. Li et al., “A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway,” Stroke, vol. 43, pp. 2764–2773, 2012.
- J. Yao, Y. Xu, F. Ji et al., “Protective effects of MLIF analogs on cerebral ischemia-reperfusion injury in rats,” Peptides, vol. 32, no. 5, pp. 1047–1054, 2011.
- J. A. Gimenez-Scherer, E. Arenas, L. Diaz, G. Rico, J. Fernandez, and R. Kretschmer, “Effect of the monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica on the expression of cell adhesion molecules (CAMs) in the skin of guinea pigs,” Archives of Medical Research, vol. 31, no. 4, pp. S92–S93, 2000.
- F. Bao, Y. Chen, G. A. Dekaban, and L. C. Weaver, “Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats,” Journal of Neurochemistry, vol. 88, no. 6, pp. 1335–1344, 2004.
- L. R. Saville, C. H. Pospisil, L. A. Mawhinney et al., “A monoclonal antibody to CD11d reduces the inflammatory infiltrate into the injured spinal cord: a potential neuroprotective treatment,” Journal of Neuroimmunology, vol. 156, no. 1-2, pp. 42–57, 2004.
- P. J. Mabon, L. C. Weaver, and G. A. Dekaban, “Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin αD: a potential new anti-inflammatory treatment,” Experimental Neurology, vol. 166, no. 1, pp. 52–64, 2000.