Hp-𝜷-CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

Table 2

Effect of the addition of different concentrations of sodium alginate and P-68 to voriconazole in situ gelling formulation on viscosity of gel, bioadhesion component, and force of bioadhesion.

Formulations	Viscosity of gel at 100 rpm (cP)	Viscosity with bioadhesive component at 100 rpm (cP)	Force of bioadhesion (dyne/cm^2)
VG1	235.7 ± 6.66	1857 ± 6.42	17.24
VG2	249.3 ± 4.93^††	1963 ± 6.55^††	18.78
VG3	262.3 ± 7.02^††	2047 ± 4.16^††	19.96
VG4	274.3 ± 5.03^††	2186 ± 2.08^††	22.08
VG5	306.3 ± 6.11^††	2236 ± 4.58^††	22.38
VG6	329.3 ± 10.5^††	2345 ± 3.21^††	23.82
VG7	355.7 ± 8.50^††	2478 ± 4.01^††	25.59
VG8	351.7 ± 28.3^††	2576 ± 3.11^††	27.59
VG9	414.3 ± 10.0^††	2698 ± 3.79^††	28.28

Values are mean ± SE of 3 gel viscosities in each group.
†Statistically significant difference at 𝑃<0.05.
††Statistically significant difference at 𝑃<0.01.
†††Statistically significant difference at 𝑃<0.001 from control (VGI containing 15% PF-127, 14% PF-68, 0.5% sodium alginate) as determined by one-way ANOVA followed by Dunnett’s test.