Hp-𝜷-CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

Table 4

Kinetic profiles of in vitro drug release from in situ gels through Millipore membrane filter and freshly excised goat cornea.

Formulations	(𝑅^2)
	Zero order		1st order		Higuchi		Korsmeyer-Peppas
	Millipore goat	Membrane cornea	Millipore goat	Membrane cornea	Millipore goat	Membrane cornea	Millipore goat	Membrane cornea	Mechanism; of drug; release
VG1	0.9286	0.8887	0.9326	0.9176	0.9505	0.9866	0.9126	0.9474	Fickian
VG2	0.9320	0.9006	0.9227	0.9128	0.9362	0.9414	0.8981	0.7705	Non-Fickian
VG3	0.9461	0.9207	0.9227	0.9269	0.9452	0.9346	0.8981	0.8073	Non-Fickian
VG4	0.9298	0.8840	0.9438	0.9077	0.9506	0.9738	0.9337	0.8922	Fickian
VG5	0.9338	0.9102	0.9402	0.9195	0.9478	0.9388	0.9015	0.7878	Fickian
VG6	0.9011	0.9250	0.8985	0.9325	0.9183	0.9428	0.9077	0.8304	Fickian
VG7	0.9376	0.8828	0.9435	0.9059	0.9560	0.9755	0.896	0.8947	Fickian
VG8	0.9587	0.9089	0.9535	0.9179	0.9620	0.9366	0.9451	0.7789	Non-Fickian
VG9	0.8812	0.9311	0.8632	0.9440	0.9034	0.9750	0.9023	0.890	Non-Fickian