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BioMed Research International
Volume 2013 (2013), Article ID 349526, 7 pages
http://dx.doi.org/10.1155/2013/349526
Review Article

Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

1St Thomas’ Hospital, Westminster Bridge Road, London SE1 7EH, UK
2The Dermatology Centre, Manchester Academic Health Science Centre, University of Manchester, Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK

Received 27 June 2012; Accepted 5 September 2012

Academic Editor: Mark Berneburg

Copyright © 2013 Christina Wlodek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.